ModelDB: Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005)

Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005)

Accession: 55748

Detailed Markov models of IKs (the slow delayed rectifier K+ current) and its alpha-subunit KCNQ1 were developed. The model is compared to experiment in the paper. The role of IKs in disease and drug treatments is elucidated (the prevention of excessive action potential prolongation and development of arrhythmogenic early afterdepolarizations). See paper for more and details.
Reference: Silva J, Rudy Y (2005) Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve. Circulation 112:1384-91 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Channel;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):	I K; KCNQ1; I_Ks;
Gap Junctions:
Receptor(s):
Gene(s):	Kv1.9 Kv7.1 KCNQ1;
Transmitter(s):
Simulation Environment:	MATLAB (web link to model);
Model Concept(s):	Activity Patterns; Ion Channel Kinetics; Action Potentials; Heart disease; Long-QT;
Implementer(s):	Silva, Jonathan [jonsilva at gmail.com];

Search NeuronDB for information about: I K; KCNQ1; I_Ks;

Model files (located externally to ModelDB) Help downloading and running models

Functional matlab code for the models in the paper

Silva J, Rudy Y. 2005
Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve.
Circulation. Sep 6;112(10):1384-91. Epub 2005 Aug 29.

are available through the following links to the Rudy lab web site:


Guinea Pig IKr (Silva and Rudy 2005) 


Guinea Pig IKs, Human KCNQ1, and Human IKs (Silva and Rudy 2005)

Here are some related models also availble at the Rudy lab web site:


INa (WT) (Clancy and Rudy 2002) 

For many of the simulations we inserted the channel models into the Luo-Rudy
model of the guinea pig ventricular action potential. The code for this
model is here

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