ModelDB: Breakdown of accmmodation in nerve: a possible role for INAp (Hennings et al 2005)

Breakdown of accmmodation in nerve: a possible role for INAp (Hennings et al 2005)

Accession: 55749

The present modeling study suggests that persistent, low-threshold, rapidly activating sodium currents have a key role in breakdown of accommodation, and that breakdown of accommodation can be used as a tool for studying persistent sodium current under normal and pathological conditions. See paper for more and details.
Reference: Hennings K, Arendt-Nielsen L, Andersen OK (2005) Breakdown of accommodation in nerve: a possible role for persistent sodium current. Theor Biol Med Model 2:16- [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Spinal motor neuron; Myelinated neuron;
Channel(s):	I Na,p; I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	MATLAB;
Model Concept(s):	Action Potential Initiation; Action Potentials; Pathophysiology; Electrotonus;
Implementer(s):	Hennings, Kristian ;

Search NeuronDB for information about: Spinal motor neuron; I K; I Na,p; I Na,t;

Model files Help downloading and running models

Functional matlab code for the models in the paper

Hennings K, Arendt-Nielsen L, Andersen OK.
Breakdown of accommodation in nerve: a possible role for persistent sodium
current.
Theor Biol Med Model. 2005 Apr 12;2(1):16.

are available in this directory.

To demonstrate Figure 1D from the paper start matlab and cd to this directory.
Cut and past the following three lines into the matlab command line:

[TS] = [10 20 30 40 50 100 150 200];
[X]  = [2.5 -20 0.5];
[T] = test_ac(X,TS);

In about six minutes on a 800 MhZ Pentium PC two graphs, an action potential
and also Figure 1D, appear.

These files were supplied by Dr Hennings.

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