ModelDB: Coding of stimulus frequency by latency in thalamic networks (Golomb et al 2005)

Coding of stimulus frequency by latency in thalamic networks (Golomb et al 2005)

Accession: 58582

The paper presents models of the rat vibrissa processing system including the posterior medial (POm) thalamus, ventroposterior medial (VPm) thalamus, and GABAB- mediated feedback inhibition from the reticular thalamic (Rt) nucleus. A clear match between the experimentally measured spike-rates and the numerically calculated rates for the full model occurs when VPm thalamus receives stronger brainstem input and weaker GABAB-mediated inhibition than POm thalamus.
Reference: Golomb D, Ahissar E, Kleinfeld D (2006) Coding of stimulus frequency by latency in thalamic networks through the interplay of GABAB-mediated feedback and stimulus shape. J Neurophysiol 95:1735-1750 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Network;
Brain Region(s)/Organism:	Thalamus;
Cell Type(s):	Thalamic relay neuron; Thalamic reticular neuron;
Channel(s):
Gap Junctions:
Receptor(s):	GabaA; GabaB; AMPA;
Gene(s):
Transmitter(s):	Gaba; Glutamate;
Simulation Environment:	C or C++ program;
Model Concept(s):	Simplified Models; Rate-coding model neurons;
Implementer(s):	Golomb, David ;

Search NeuronDB for information about: Thalamic relay neuron; Thalamic reticular neuron; AMPA; GabaA; GabaB; Gaba; Glutamate;

Model files Help downloading and running models

Model of a thalamic network, according to the paper:

Golomb D, Ahissar E, Kleinfeld D.
Coding of stimulus frequency by latency in thalamic networks through 
the interplay of GABAB-mediated feedback and stimulus shape.
J Neurophysiol. 2005 Nov 2; [Epub ahead of print] 

The program is composed of several C programs and files:

tlp.c    : main simulation program.
tplp.c   : part of the tlp.c program. It separates the columns of tlp.col.?? 
          and calculate properties of the "PSTHs".

plp.c    : independent program. It separates the columns of tlp.col.?? .
stm.c    : used for plotting the stimuli. 
intnor.c : Integrate the activity trace  - modeling results (to compute the
           normalized firing rates).

nr.c  : routines from the library "Numerical Recipes" (only few of them
        are needed for this program).

The file tlp.n.d1 is the parameter file for tlp.c.
The file tlp.nps is the parameter file for tplp.c.
The file plp.n is the parameter file for plp.c.


Experimental results (from Sosnik et al., J. Neurophysiol., 86:339-353, 2001):

intg.res.a3 - integrated PSTH for VPm.
intg.res.a4 - integrated PSTH for POm.
delay_exp - delays.

The file ptrint.com is a Unix/Linux command procedure.

Commands (for a Unix/Linux operating system):

To compile the programs

make tlp
make plp
make stm
make intnor

to run the programs and generate figure 7A-H in the paper:

ptrint.com

You should have the graphic program xmgrace.

If you have any questions or problems, E-mail me to golomb@bgu.ac.il .

  David Golomb

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