| An integrative model of the cardiac ventricular myocytes (Greenstein and Winslow 2002) |
| Accession: 62286 |
The local control theory of excitation-contraction (EC) coupling
in cardiac muscle asserts that L-type Ca2+ current tightly
controls Ca2+ release from the sarcoplasmic reticulum (SR) via
local interaction of closely apposed L-type Ca2+ channels (LCCs)
and ryanodine receptors (RyRs). ...In this study we present a
biophysically detailed model of the normal canine ventricular
myocyte that conforms to local control theory. The model
formulation incorporates details of microscopic EC coupling
properties in the form of Ca2+ release units (CaRUs) in which individual sarcolemmal LCCs interact in a stochastic manner with
nearby RyRs in localized regions ... See paper for more and
details.
Reference: Greenstein JL, Winslow RL (2002) An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release. Biophys J 83:2918-45 [PubMed] |
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Readme.html for a web-link to the model code associated with the paper:
Greenstein JL, Winslow RL. (2002)
An integrative model of the cardiac ventricular myocyte incorporating local
control of Ca2+ release.
Biophys J. Dec;83(6):2918-45.
The model code is available from
http://www.ccbm.jhu.edu/software/clrcv.php
Please note that to download this model you will need to (free)
register at the Center for Cardiovascular Bioinformatics and Modeling
web site:
http://www.ccbm.jhu.edu/others/register.php
How to run the model:
Simply start the model by typing
Script_40state
after cd'ing to the directory created when you download and expanded the zip
file.
After a minute or so a figure similar to figure 11A from the paper will appear:
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