ModelDB: Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites (Golding et al 2001)

Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites (Golding et al 2001)

Accession: 64167

From reference below and Corrigendum: J Neurophysiol 87:1a, 2002 (better versions of figures 2, 3, 5 and 7 because of poor print quality in the original article; as of 2/2006, these figures are perfectly fine in the PDF of the original article that is currently available from the publisher's WWW site). Examines the anatomical and biophysical factors that account for the fact that retrograde invasion of spikes into the apical dendritic tree past 300 um succeeds in some CA1 pyramidal neurons but fails in others.
Reference: Golding NL, Kath WL, Spruston N (2001) Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites. J Neurophysiol 86:2998-3010 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	CA1 pyramidal neuron;
Channel(s):	I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron (web link to model);
Model Concept(s):	Dendritic Action Potentials; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials;
Implementer(s):	Spruston, Nelson [Spruston at Northwestern.edu]; Golding, Nace L [golding at mail.utexas.edu]; Kath, William L [kath at northwestern.edu]; Mickus, Timothy ;

Search NeuronDB for information about: CA1 pyramidal neuron; I Na,t; I A; I K;

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Spruston / Kath main

"Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites"

Nace L. Golding, William L. Kath, and Nelson Spruston

Journal of Neurophysiology, 2001

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