ModelDB: Dynamical model of olfactory bulb mitral cell (Rubin, Cleland 2006)

Dynamical model of olfactory bulb mitral cell (Rubin, Cleland 2006)

Accession: 64296

This four-compartment mitral cell exhibits endogenous subthreshold oscillations, phase resetting, and evoked spike phasing properties as described in electrophysiological studies of mitral cells. It is derived from the prior work of Davison et al (2000) and Bhalla and Bower (1993). See readme.txt for details.
Reference: Rubin DB, Cleland TA (2006) Dynamical mechanisms of odor processing in olfactory bulb mitral cells. J Neurophysiol 96(2):555-568 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Olfactory bulb mitral cell;
Channel(s):	I Na,p; I Na,t; I L high threshold; I A; I K; I K,leak; I h; I K,Ca; I Sodium; I Calcium; I Potassium; I A, slow;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Bursting; Temporal Pattern Generation; Oscillations; Synchronization; Simplified Models; Delay;
Implementer(s):	Rubin, Daniel B ;

Search NeuronDB for information about: Olfactory bulb mitral cell; I Na,p; I Na,t; I L high threshold; I A; I K; I K,leak; I h; I K,Ca; I Sodium; I Calcium; I Potassium; I A, slow;

Model files

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Mitral cell model for dynamical olfactory bulb networks

From:
 	Rubin D, Cleland TA (2006) 
	Dynamical mechanisms of odor processing in olfactory bulb 
	mitral cells.  
	J Neurophysiology.

This model mitral cell (the principal output neuron of the vertebrate 
olfactory bulb) comprises four compartments (soma, apical dendrite, 
apical tuft, lateral dendrite) and exhibits endogenous subthreshold 
oscillations, phase resetting, and evoked spike phasing properties 
as described in mitral cells by:

  (1) Desmaisons D, Vincent JD, Lledo PM (1999) 
	Control of action potential timing by intrinsic subthreshold 
	oscillations in olfactory bulb output neurons.  
	J Neuroscience 29(24):10727-10737.
  (2) Balu R, Larimer P, Strowbridge BW (2004)
	Phasic stimuli evoke precisely timed spikes in intermittently 
	discharging mitral cells.
	J Neurophysiology 92(2):743-753.
  (3) Chen WR, Shepherd GM (1997) 
	Membrane and synaptic properties of mitral cells in slices of 
	rat olfactory bulb.
	Brain Research 745(1-2):189-196.
  (4) Heyward P, Ennis M, Keller A, Shipley MT (2001) 
	Membrane bistability in olfactory bulb mitral cells.
	J Neuroscience 21(14):5311-5320.
	
Adapted from the model of:
	Davison AP, Feng J and Brown D. (2000) A reduced compartmental model 
	of the mitral cell for use in network models of the olfactory bulb.
      Brain Research Bulletin 51(5): 393-399.

Run the model using the file mosinit.hoc after compiling the .mod files.

An xpanel will appear enabling easy recreation of many figures from the 
2006 paper.  Be patient on slower machines as traces will by default only 
become visible after 1600-2000 ms computed time.  Parameters can be derived 
from the xpanel code or from the tables in the 2006 paper.  

For more information contact Thomas Cleland (tac29@cornell.edu).

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