ModelDB: CA1 pyramidal neuron: conditional boosting of dendritic APs (Watanabe et al 2002)

CA1 pyramidal neuron: conditional boosting of dendritic APs (Watanabe et al 2002)

Accession: 7386

Model files from the paper Watanabe S, Hoffman DA, Migliore M, Johnston D (2002). The experimental and modeling results support the hypothesis that dendritic K-A channels and the boosting of back-propagating action potentials contribute to the induction of LTP in CA1 neurons. See the paper for details. Questions about the model may be addressed to Michele Migliore: michele.migliore@pa.ibf.cnr.it
Reference: Watanabe S, Hoffman DA, Migliore M, Johnston D (2002) Dendritic K+ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons. Proc Natl Acad Sci U S A 99:8366-8371 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	CA1 pyramidal neuron;
Channel(s):	I Na,t; I A; I K;
Gap Junctions:
Receptor(s):	AMPA;
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Dendritic Action Potentials; Coincidence Detection; Active Dendrites; Detailed Neuronal Models; Action Potentials;
Implementer(s):	Migliore, Michele [Michele.Migliore at Yale.edu];

Search NeuronDB for information about: CA1 pyramidal neuron; AMPA; I Na,t; I A; I K;

Model files

Help downloading and running models

NEURON mod files from the paper:
S. Watanabe, D.A. Hoffman, M. Migliore, and D. Johnston
Dendritic K+ channels contribute to spike-timing dependent 
long-term potentiation in hippocampal pyramidal neurons 
Proc.Natl.Acad.Sci. USA 99:8366-8371, 2002.

The fig6.hoc simulation file will show the membrane potential
in a distal dendrite (350um from soma) for three simulations,
as in Fig.6 of the paper.
In each case two APs are elicited, unpaired with EPSPs
or paired with EPSPs after a 35 or 45ms delay.
The simulations show that the APs in the dendrites are boosted
only when they are paired with coincident EPSPs. 

Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui fig6.hoc

Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
fig6.hoc 
will open the simulation window.

Questions on how to use this model with NEURON
should be directed to michele.migliore@pa.ibf.cnr.it

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