ModelDB: Hippocampus temporo-septal engram shift model (Lytton 1999)

Hippocampus temporo-septal engram shift model (Lytton 1999)

Accession: 7400

Temporo-septal engram shift model of hippocampal memory. The model posits that memories gradually move along the hippocampus from a temporal encoding site to ever more septal sites from which they are recalled. We propose that the sense of time is encoded by the location of the engram along the temporo-septal axis.
Reference: Lytton WW, Lipton P (1999) Can the hippocampus tell time? The temporo-septal engram shift model. Neuroreport 10:2301-6 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Network;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):
Channel(s):	I Na,t; I K;
Gap Junctions:
Receptor(s):	GabaA; AMPA;
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Pattern Recognition; Temporal Pattern Generation; Spatio-temporal Activity Patterns; Simplified Models;
Implementer(s):	Lytton, William [billl at neurosim.downstate.edu];

Search NeuronDB for information about: GabaA; AMPA; I Na,t; I K;

Model files

Help downloading and running models

Lytton WW; Lipton P. Can the hippocampus tell time?: The
temporo-septal engram shift model.
Neuroreport, 10:2301--2306, 1999.

This example produces Fig. 1 p 2302 as shown in fig1.gif.  The
simulation takes several minutes and the progress is indicated in the
console window by printing the time approximately every 300 ms.  At 5000
ms, the figure will be displayed in two graph windows.  The raster plot
will probably be hidden underneath the plot of Net[20].soma.v(0.5)
NB: the first cycle of stimulation produces an initialization artifact
(bursting in all cells) that is not shown in the original figure. 

For questions about the model contact Bill Lytton at
billl@neurosim.downstate.edu

Michael Hines made some non-substantive changes to vecst.mod (derived
from vecst.mod.orig) to allow running the model under mswin and on the
mac.  The most significant being the incorporation of a free version of
srand/drand from
http://www.mit.edu/afs/athena/activity/c/cgs/src/math/drand48/
 Under mswin, this model can only be run using NEURON version 5.2
2002/02/28 or later since it makes use of calls to sprintf and
hoc_obj_file_arg which were not exported by earlier versions.  On a MAC
you may need to increase the memory size for NEURON to 24MB.

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