To better understand population phenomena in thalamocortical neuronal ensembles,
we have constructed a preliminary network model with 3,560 multicompartment neurons
(containing soma, branching dendrites, and a portion of axon). Types of neurons included
superficial pyramids (with regular spiking [RS] and fast rhythmic bursting [FRB] firing
behaviors); RS spiny stellates; fast spiking (FS) interneurons, with basket-type and axoaxonic
types of connectivity, and located in superficial and deep cortical layers; low threshold spiking
(LTS) interneurons, that contacted principal cell dendrites; deep pyramids, that could have RS or
intrinsic bursting (IB) firing behaviors, and endowed either with non-tufted apical dendrites or
with long tufted apical dendrites; thalamocortical relay (TCR) cells; and nucleus reticularis
(nRT) cells. To the extent possible, both electrophysiology and synaptic connectivity were
based on published data, although many arbitrary choices were necessary.
References:
1. Traub RD, Contreras D, Cunningham MO, Murray H, Lebeau FE, Roopun A, Bibbig A, et al (2005) A single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles and epileptogenic bursts: Appendix B. J Neurophysiol 93(4):2194-232 [PubMed]
2. Traub RD, Contreras D, Whittington MA (2005) Combined experimental-simulation studies of cellular and network mechanisms of epileptogenesis in vitro and in vivo. J Clin Neurophysiol 22:330-42 [PubMed] |
