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Low dose of dopamine may stimulate prolactin secretion by increasing K currents (Tabak et al. 2006)
Accession: 91898
".. We considered the fast K+ currents flowing through large-conductance BK channels and through A-type channels. We developed a minimal lactotroph model to investigate the effects of these two currents. Both IBK and IA could transform the electrical pattern of activity from spiking to bursting, but through distinct mechanisms. IBK always increased the intracellular Ca2+ concentration, while IA could either increase or decrease it. Thus, the stimulatory effects of DA could be mediated by a fast K+ conductance which converts tonically spiking cells to bursters. In addition, the study illustrates that a heterogeneous distribution of fast K+ conductances could cause heterogeneous lactotroph firing patterns."
Reference: Tabak J, Toporikova N, Freeman ME, Bertram R (2007) Low dose of dopamine may stimulate prolactin secretion by increasing fast potassium currents. J Comput Neurosci 22:211-222 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type:  Neuron or other electrically excitable cell;
Brain Region(s)/Organism:  
Cell Type(s):   Pituitary cell ;
Channel(s):  I K; I K,Ca; I Calcium;  
Gap Junctions:  
Receptor(s):  
Gene(s):  
Transmitter(s):  Dopamine;
Simulation Environment:  XPP (web link to model);
Model Concept(s):  Bursting; Oscillations;
Implementer(s):  
Search NeuronDB for information about:  I K; I K,Ca; I Calcium; Dopamine;
Model files (located externally to ModelDB) Help downloading and running models
richard bertram--computer software Note from ModelDB Administrator: The below web page is a copy of http://www.math.fsu.edu/~bertram/software/pituitary/ made on May 8th, 2007 The Tabak et al. 2007 link is at the bottom.
Software for Hypothalamus-Pituitary Interactions
The computer programs below are listed according to the articles in which they appear. They run with the XPPAUT computer software. XPPAUT is free, and runs on Unix, Linux, and Windows machines. It can be downloaded from the website of Bard Ermentrout .
  • Egli, Bertram, Sellix, and Freeman
    "Rhythmic Secretion of Prolactin in Rats: Action of Oxytocin Coordinated by Vasoactive Intestinal Polypeptide of Suprachiasmatic Nucleus Origin", Endocrinology, vol. 145, pp. 3386-3394, 2004. Endo_04.ode

  • Egli, Bertram, Toporikova, Sellix, Blanco, and Freeman
    "Prolactin Secretory Rhythm of Mated Rats Induced by a Single Injection of Oxytocin", American Journal of Physiology, vol. 290, pp. E566-E572, 2006. AJP_06a.ode

  • Bertram, Egli, Toporikova, and Freeman
    "A Mathematical Model for the Mating-Induced Prolactin Rhythm of Female Rats", American Journal of Physiology, vol. 290, pp. E573-E582, 2006. AJP_06b

  • Bertram, Tabak, Toporikova, and Freeman
    "Endothelin Action on Pituitary Lactotrophs: One receptor, Many GTP-Binding Proteins", Science STKE, 2006(319):pe4, 2006. STKE_06

  • Tabak, Toporikova, Freeman, and Bertram
    "Low Dose of Dopamine may Stimulate Prolactin Secretion by Increasing Fast Potassium Currents", Journal of Computational Neuroscience, vol. 22, pp. 211-222, 2007. JCNS_07.ode


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