ModelDB: Fast-spiking cortical interneuron (Golomb et al. 2007)

Fast-spiking cortical interneuron (Golomb et al. 2007)

Accession: 97747

Cortical fast-spiking (FS) interneurons display highly variable electrophysiological properties. We hypothesize that this variability emerges naturally if one assumes a continuous distribution of properties in a small set of active channels. We construct a minimal, single-compartment conductance-based model of FS cells that includes transient Na+, delayed-rectifier K+, and slowly inactivating d-type K+ conductances. The model may display delay to firing. Stuttering (elliptic bursting) and subthreshold oscillations may be observed for small Na+ window current.
Reference: Golomb D, Donner K, Shacham L, Shlosberg D, Amitai Y, Hansel D (2007) Mechanisms of Firing Patterns in Fast-Spiking Cortical Interneurons. PLoS Comput Biol 3:e156- [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Fast-spiking cortical interneuron;
Channel(s):	I Na,t; I K; I A, slow;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron; XPP;
Model Concept(s):	Bursting; Action Potentials; Stuttering; Delay;
Implementer(s):

Search NeuronDB for information about: I A, slow; I K; I Na,t;

Model files

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This is the readme for the model associated with the paper:

Golomb D, Donner K, Shacham L, Shlosberg D, Amitai Y, Hansel D (2007)
Mechanisms of Firing Patterns in Fast-Spiking Cortical
Interneurons. PLoS Comput Biol 3:e156

This XPP file was supplied by Dr David Golomb
golomb@bgu.ac.il

Usage Instructions:

Load the model with a command like
xppaut gah_fig2c.ode

Start the simulation by clicking on
Initialconds -> (G)o

You will see a reproduction of fig2c:

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