ModelDB: Mammalian Ventricular Cell (Beeler and Reuter 1977)

Mammalian Ventricular Cell (Beeler and Reuter 1977)

Accession: 97863

This classic model of ventricular myocardial fibres was implemented by Francois Gannier. "... Four individual components of ionic current were formulated mathematically in terms of Hodgkin-Huxley type equations. The model incorporates two voltage- and time-dependent inward currents, the excitatory inward sodium current, illa, and a secondary or slow inward current, is, primarily carried by calcium ions. A time-independent outward potassium current, iK1, exhibiting inward-going rectification, and a voltage- and time-dependent outward current, i.1, primarily carried by potassium ions, are further elements of the model...."
Reference: Beeler GW, Reuter H (1977) Reconstruction of the action potential of ventricular myocardial fibres. J Physiol 268:177-210 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Cardiac ventricular cell;
Channel(s):	I K; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Ion Channel Kinetics; Action Potentials;
Implementer(s):	Gannier, Francois ;

Search NeuronDB for information about: I Calcium; I K; I Potassium; I Sodium;

Model files

Help downloading and running models


This is an implementation by Francois Gannier of the model associated
with the paper:

Beeler GW, Reuter H (1977) Reconstruction of the action potential of
ventricular myocardial fibres. J Physiol 268:177-210

To run the simulation auto-launch the model from modeldb or download
and extract the archive and then compile the mod files under:

unix/linux:
-----------
type nrnivmodl in the beelerReuter folder and then
nrngui mosinit.hoc

mswin:
------
run mknrndll and then double click on mosinit.hoc

MAC OS X:
--------

Drag and drop the beelerReuter folder onto the mknrndll icon.  Drag
and drop the mosinit.hoc file onto the nrngui icon.

Once the simulation starts it recreates a figure similar to Fig. 6 A, B:

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