ModelDB: Fronto-parietal visuospatial WM model with HH cells (Edin et al 2007)

Fronto-parietal visuospatial WM model with HH cells (Edin et al 2007)

Accession: 98017

1) J Cogn Neurosci: 3 structural mechanisms that had been hypothesized to underlie vsWM development during childhood were evaluated by simulating the model and comparing results to fMRI. It was concluded that inter-regional synaptic connection strength cause vsWM development. 2) J Integr Neurosci: Given the importance of fronto-parietal connections, we tested whether connection asymmetry affected resistance to distraction. We drew the conclusion that stronger frontal connections are benefiction. By comparing model results to EEG, we concluded that the brain indeed has stronger frontal-to-parietal connections than vice versa.
Reference: Edin F, Macoveanu J, Olesen P, Tegner J, Klingberg T (2007) Stronger synaptic connectivity as a mechanism behind development of working memory-related brain activity during childhood. J Cogn Neurosci 19:750-60 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Network;
Brain Region(s)/Organism:	Neocortex;
Cell Type(s):	Neocortical pyramidal neuron: superficial; Wang-Buzsaki neuron;
Channel(s):
Gap Junctions:	Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Working memory; Attractor Neural Network;
Implementer(s):

Search NeuronDB for information about: Neocortical pyramidal neuron: superficial;

Model files

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SFS-IPS-WM-network

MultiModuleWMNetXP.hoc

SingleCellLab.hoc

driftdiffusion.m

extract_sim_dirs.m

fig4_test_070103.m

compareCatalogs.m

SERIES_testDTF.txt

showConnMulti.m

showSimulation.m

These are the model files associated with the publications:

Edin F, Macoveanu J, Olesen P, Tegner J, Klingberg T (2007) Stronger
synaptic connectivity as a mechanism behind development of working
memory-related brain activity during childhood. J Cogn Neurosci
19:750-60

Edin F et al. J Integr Neurosci. 2007 Dec.

These files were supplied by Fredrik Edin.

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