ModelDB: Myelinated axon conduction velocity (Brill et al 1977)

Myelinated axon conduction velocity (Brill et al 1977)

Accession: 9848

Examines conduction velocity as function of internodal length.
Reference: Brill MH, Waxman SG, Moore JW, Joyner RW (1977) Conduction velocity and spike configuration in myelinated fibres: computed dependence on internode distance. J Neurol Neurosurg Psychiatry 40:769-74 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Axon;
Brain Region(s)/Organism:
Cell Type(s):	Myelinated neuron;
Channel(s):	I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Axonal Action Potentials;
Implementer(s):	Hines, Michael [Michael.Hines at Yale.edu];

Search NeuronDB for information about: I Na,t; I K;

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Brill, Waxman, Moore, and Joyner (1977) Conduction velocity and spike
configuration in myelinated fibres: Computed dependence on internode distance
J. Neurology, Neurosurgery, and Psychiatry. 40: 769-774

This model reproduces figures 1 and 2. On launch it simulates fig 2b.
Note that the myelin locations for voltage plots for fig 2b differ from the
paper by half a segment length. That is, in the paper the locations are at
x=.1, .2, .3, ..., .9 whereas in this simulation the centers of the 10 myelin
segments are at x = .05, .15, .25, ..., .95

The NEURON implementation of this model was prepared by Michael Hines.
Questions about details of this implementation should be addressed to him
at michael.hines@yale.edu.

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