ModelDB: Conduction in uniform myelinated axons (Moore et al 1978)

Conduction in uniform myelinated axons (Moore et al 1978)

Accession: 9851

Examines the relative sensitivity of the velocity of impulse propagation to changes in nodal and internodal parameters.
Reference: Moore JW, Joyner RW, Brill MH, Waxman SD, Najar-Joa M (1978) Simulations of conduction in uniform myelinated fibers. Relative sensitivity to changes in nodal and internodal parameters. Biophys J 21:147-60 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Axon;
Brain Region(s)/Organism:
Cell Type(s):	Myelinated neuron;
Channel(s):	I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Axonal Action Potentials; Multiple sclerosis;
Implementer(s):	Hines, Michael [Michael.Hines at Yale.edu];

Search NeuronDB for information about: I Na,t; I K;

Model files

Help downloading and running models

Moore, Joyner, Brill, Waxman, and Najar-Joa. (1978) Simulations of
conduction in uniform myelinated fibers: Relative sensitivity to
changes in nodal and internodal parameters.
Biophys. J. 21:147-160.

This model reproduces figures 2 and 3.
The standard temperature for the conductance Q10's is not specified
in the paper. However, fig 3 seems to give quantitatively similar results
when the choice for the "All Q10's" curve is a standard temperature of 0 degC.

The NEURON implementation of this model was prepared by Michael Hines.
Questions about details of this implementation should be addressed to him
at michael.hines@yale.edu.

ModelDB Home SenseLab Home Help
Questions, comments, problems? Email the ModelDB Administrator
How to cite ModelDB
This site is Copyright 2012 Shepherd Lab, Yale University