ModelDB: Models that contain the Model Topic : Pathophysiology

Models that contain the Model Topic : Pathophysiology

(The physiology (specific functions) associated with a condition in which the normal functioning of an animal is impaired.)

Models
A Neural mass computational model of the Thalamocorticothalamic circuitry (Bhattacharya et al. 2011)
A cardiac cell simulator (Puglisi and Bers 2001), applied to the QT interval (Busjahn et al 2004)
A dynamic model of the canine ventricular myocyte (Hund, Rudy 2004)
A dynamical model of the basal ganglia (Leblois et al 2006)
A method of counting motor units in mice (Major et al 2007)
A neural model of Parkinson`s disease (Cutsuridis and Perantonis 2006, Cutsuridis 2006, 2007)
A single column thalamocortical network model (Traub et al 2005)
A spatially extended model for macroscopic spike-wave discharges (Taylor and Baier 2011)
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Amyloid beta (IA block) effects on a model CA1 pyramidal cell (Morse et al. 2010)
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
Basal ganglia network model of subthalamic deep brain stimulation (Hahn and McIntyre 2010)
Basal ganglia-thalamic network model for deep brain stimulation (So et al. 2011)
Basal ganglia-thalamocortical loop model of action selection (Humphries and Gurney 2002)
Breakdown of accmmodation in nerve: a possible role for INAp (Hennings et al 2005)
CA1 pyramidal cell: reconstructed axonal arbor and failures at weak gap junctions (Vladimirov 2011)
CA1 pyramidal neuron to study INaP properties and repetitive firing (Uebachs et al. 2010)
CA1 pyramidal neuron: Ih current (Migliore et al. 2012)
CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
CA1 pyramidal neuron: h channel-dependent deficit of theta oscill. resonance (Marcelin et al. 2008)
CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)
CA1 pyramidal neurons: effects of Alzheimer (Culmone and Migliore 2012)
Cardiac Atrial Cell (Courtemanche et al 1998)
Cardiac Atrial Cell (Courtemanche et al 1998) (C++)
Cardiac action potential based on Luo-Rudy phase 1 model (Luo and Rudy 1991), (Wu 2004)
Complex CA1-neuron to study AP initiation (Wimmer et al. 2010)
Computational Surgery (Lytton et al. 2011)
Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)
Computer model of clonazepam`s effect in thalamic slice (Lytton 1997)
Computer simulations of neuron-glia interactions mediated by ion flux (Somjen et al. 2008)
Conduction in uniform myelinated axons (Moore et al 1978)
Consequences of HERG mutations in the long QT syndrome (Clancy, Rudy 2001)
Contribution of ATP-sensitive potassium channels in the neuronal network (Huang et al. 2009)
Cortical network model of posttraumatic epileptogenesis (Bush et al 1999)
D2 dopamine receptor modulation of interneuronal activity (Maurice et al. 2004)
Demyelinated and remyelinating axon conductances (Hines, Shrager 1991)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Santhakumar et al 2005)
Dopamine-modulated medium spiny neuron, reduced model (Humphries et al. 2009)
Dorsal root ganglion (DRG) neuronal model (Kovalsky et al. 2009)
Dynamic dopamine modulation in the basal ganglia: Learning in Parkinson (Frank et al 2004,2005)
Efffect of propofol on potassium current in cardiac H9c2 cells (Liu et al. 2008)
Epilepsy may be caused by very small functional changes in ion channels (Thomas et al. 2009)
Epileptic seizure model with Morris-Lecar neurons (Beverlin and Netoff 2011)
Experimental and modeling studies of desensitization of P2X3 receptors (Sokolova et al. 2006)
Explaining pathological changes in axonal excitability by dynamical analysis (Coggan et al. 2011)
FS Striatal interneuron: K currents solve signal-to-noise problems (Kotaleski et al 2006)
Failure of Deep Brain Stimulation in a basal ganglia neuronal network model (Dovzhenok et al. 2013)
Febrile seizure-induced modifications to Ih (Chen et al 2001)
Functional consequences of cortical circuit abnormalities on gamma in schizophrenia (Spencer 2009)
GP Neuron, somatic and dendritic phase response curves (Schultheiss et al. 2011)
GPi/GPe neuron models (Johnson and McIntyre 2008)
Globus pallidus multi-compartmental model neuron with realistic morphology (Gunay et al. 2008)
HERG K+ channels spike-frequency adaptation (Chiesa et al 1997)
HMM of Nav1.7 WT and F1449V (Gurkiewicz et al. 2011)
High frequency stimulation of the Subthalamic Nucleus (Rubin and Terman 2004)
Human Attentional Networks: A Connectionist Model (Wang and Fan 2007)
Huntington`s disease model (Gambazzi et al. 2010)
Hysteresis in voltage gating of HCN channels (Elinder et al 2006, Mannikko et al 2005)
INa and IKv4.3 heterogeneity in canine LV myocytes (Flaim et al 2006)
Investigation of different targets in deep brain stimulation for Parkinson`s (Pirini et al. 2009)
Ionic basis of alternans and Timothy Syndrome (Fox et al. 2002), (Zhu and Clancy 2007)
JitCon: Just in time connectivity for large spiking networks (Lytton et al. 2008)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Kinetic properties of voltage gated Na channel (Nayak and Sikdar 2007)
Kinetics of the P2X7 receptor as expressed in Xenopus oocytes (Riedel et al. 2007a,b)
Kv4.3, Kv1.4 encoded K channel in heart cells & tachy. (Winslow et al 1999, Greenstein et al 2000)
Kv4.3, Kv1.4 encoded K(+) channel in heart cells (Greenstein et al 2000) (XPP)
Markov models of SCN1A (NaV1.1) applied to abnormal gating and epilepsy (Clancy and Kass 2004)
Markovian model for cardiac sodium channel (Clancy, Rudy 2002)
Markovian model for single-channel recordings of Ik_1 in ventricular cells (Matsuoka et al 2003)
Mechanisms of very fast oscillations in axon networks coupled by gap junctions (Munro, Borgers 2010)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
Models of Na channels from a paper on the PKC control of I Na,P (Baker 2005)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
Na channel mutations in the dentate gyrus (Thomas et al. 2009)
Nav1.6 sodium channel model in globus pallidus neurons (Mercer et al. 2007)
Neocort. pyramidal cells subthreshold somatic voltage controls spike propagation (Munro Kopell 2012)
Network model with dynamic ion concentrations (Ullah et al. 2009)
Network model with neocortical architecture (Anderson et al. 2011 plus under review paper)
Neuronal population models of intracerebral EEG (Wendling et al. 2005)
Nigral dopaminergic neurons: effects of ethanol on Ih (Migliore et al. 2008)
Nodes of Ranvier with left-shifted Nav channels (Boucher et al. 2012)
Optimal deep brain stimulation of the subthalamic nucleus-a computational study (Feng et al. 2007)
Paradoxical GABA-mediated excitation (Lewin et al. 2012)
Periodicity in Na channel properties alters model neuron excitability (Majumdar and Sikdar 2007)
Persistent synchronized bursting activity in cortical tissues (Golomb et al 2005)
Phase response curve of a globus pallidal neuron (Fujita et al. 2011)
Population-level model of the basal ganglia and action selection (Gurney et al 2001, 2004)
Prefrontal–striatal Parkinsons comp. model of multicue category learning (Moustafa and Gluck 2011)
Principles of Computational Modelling in Neuroscience (Book) (Sterratt et al. 2011)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reciprocal regulation of rod and cone synapse by NO (Kourennyi et al 2004)
Rejuvenation model of dopamine neuron (Chan et al. 2007)
Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005)
Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005) (XPP)
Roles of subthalamic nucleus and DBS in reinforcement conflict-based decision making (Frank 2006)
Simulation study of Andersen-Tawil syndrome (Sung et al 2006)
Single neuron with ion concentrations to model anoxic depolarization (Zandt et al. 2011)
Small world networks of Type I and Type II Excitable Neurons (Bogaard et al. 2009)
Sodium channel mutations causing generalized epilepsy with febrile seizures + (Barela et al. 2006)
Spike trains in Hodgkin–Huxley model and ISIs of acupuncture manipulations (Wang et al. 2008)
Spiking neuron model of the basal ganglia (Humphries et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Striatal GABAergic microcircuit, dopamine-modulated cell assemblies (Humphries et al. 2009)
Studies of stimulus parameters for seizure disruption using NN simulations (Anderson et al. 2007)
Study of augmented Rubin and Terman 2004 deep brain stim. model in Parkinsons (Pascual et al. 2006)
Submyelin Potassium accumulation in Subthalamic neuron (STN) axons (Bellinger et al. 2008)
T channel currents (Vitko et al 2005)
TTX-R Na+ current effect on cell response (Herzog et al 2001)
TTX-R Na+ current effect on cell response (Herzog et al 2001) (MATLAB)
Thalamic transformation of pallidal input (Hadipour-Niktarash 2006)
Thalamocortical model of spike and wave seizures (Suffczynski et al. 2004)
The role of ATP-sensitive potassium channels in a hippocampal neuron (Huang et al. 2007)
Tonic neuron in spinal lamina I: prolongation of subthreshold depol. (Prescott and De Koninck 2005)
Tonic-clonic transitions in a seizure simulation (Lytton and Omurtag 2007)
Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +10 other papers!)
Zonisamide-induced inhibition of the firing of APs in hippocampal neurons (Huang et al. 2007)

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