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Temporal integration by stochastic recurrent network (Okamoto et al. 2007)
Accession: 105501
"Temporal integration of externally or internally driven information is required for a variety of cognitive processes. This computation is generally linked with graded rate changes in cortical neurons, which typically appear during a delay period of cognitive task in the prefrontal and other cortical areas. Here, we present a neural network model to produce graded (climbing or descending) neuronal activity. Model neurons are interconnected randomly by AMPA-receptor–mediated fast excitatory synapses and are subject to noisy background excitatory and inhibitory synaptic inputs. In each neuron, a prolonged afterdepolarizing potential follows every spike generation. Then, driven by an external input, the individual neurons display bimodal rate changes between a baseline state and an elevated firing state, with the latter being sustained by regenerated afterdepolarizing potentials. ..."
Reference: Okamoto H, Isomura Y, Takada M, Fukai T (2007) Temporal integration by stochastic recurrent network dynamics with bimodal neurons. J Neurophysiol 97:3859-67 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type:  Network;
Brain Region(s)/Organism:  Neocortex;
Cell Type(s):   
Channel(s):  I Calcium;  
Gap Junctions:  
Receptor(s):  GabaA; AMPA;
Gene(s):  
Transmitter(s):  
Simulation Environment:  C or C++ program;
Model Concept(s):  Activity Patterns;
Implementer(s):  
Search NeuronDB for information about:  GabaA; AMPA; I Calcium;
Model files   Download zip file             Help downloading and running models
\
Okamoto_etal
readme.html
screenshot.jpg
Okamoto_etal_program.c
                            
This is the readme file for the model associated with:

Okamoto H, Isomura Y, Takada M, Fukai T (2007) Temporal integration by
stochastic recurrent network dynamics with bimodal neurons. J
Neurophysiol 97:3859-67

Usage:

Compile the ansi C program with, for example under linux:

gcc -o run.exe Okamoto_etal_program.c -lm

then type
./run.exe
and enter a numerical seed for the random number generator.

The program finishes in less than a minute and produces two data files
whose graphs should look like:

screenshot


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