ModelDB: STDP depends on dendritic synapse location (Letzkus et al. 2006)

STDP depends on dendritic synapse location (Letzkus et al. 2006)

Accession: 108459

This model was published in Letzkus, Kampa & Stuart (2006) J Neurosci 26(41):10420-9. The simulation creates several plots showing voltage and NMDA current and conductance changes at different apical dendritic locations in layer 5 pyramidal neurons during STDP induction protocols. Created by B. Kampa (2006).
Reference: Letzkus JJ, Kampa BM, Stuart GJ (2006) Learning Rules for Spike Timing-Dependent Plasticity Depend on Dendritic Synapse Location J Neurosci 26:10420-10429 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Neocortical pyramidal neuron: deep;
Channel(s):	I L high threshold; I T low threshold; I A; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):	NMDA;
Gene(s):
Transmitter(s):	Glutamate;
Simulation Environment:	Neuron;
Model Concept(s):	Dendritic Action Potentials; Bursting; Active Dendrites; Synaptic Plasticity; Long-term Synaptic Plasticity; Action Potentials; STDP; Calcium dynamics;
Implementer(s):	Kampa, Bjorn M [Bjoern.Kampa at anu.edu.au];

Search NeuronDB for information about: Neocortical pyramidal neuron: deep; NMDA; I L high threshold; I T low threshold; I A; I M; I K,Ca; I Sodium; I Calcium; I Potassium; Glutamate;

Model files

Help downloading and running models Versions

This is the readme for the model published in 

Letzkus, Kampa & Stuart (2006) Learning Rules for Spike
Timing-Dependent Plasticity Depend on Dendritic Synapse Location.
J Neurosci 26(41):10420-9.

The simulation creates several plots showing voltage and NMDA current
and conductance changes at different apical dendritic locations in
layer 5 pyramidal neurons during STDP induction protocols.

Usage:

Autolaunch from ModelDB **or** download and extract the archive and
then compile the mod files in the mod directory and run under ...

linux/unix
----------
by typing
nrnivmodl mod
in the top level directory.  Then type
nrngui mosinit.hoc

mswin
-------

by running mknrndll, cd'ing to the mod directory and press make
nrnmech.dll button.  Copy the nrnmech.dll file to the parent directory
of the mod folder (the top-level directory).  Double click on the
mosinit.hoc file.

MAC OS X
--------

drag and drop the mod folder onto mknrndll icon in the NEURON
application folder.  Start a terminal window, cd to the directory
within the expanded archive and type 
mod/powerpc/special mosinit.hoc -
to start the simulation.

-------

Choose a pre-post interval (default +10 ms, i.e. post- synaptic action
potentials occur 10 ms after presynaptic EPSP stimulation). Dendritic
locations are 200 microns (proximal) or 800 microns (distal) from soma
as shown in figure 8 in Letzkus (2006).

Running the model in the default configuration should lead to:



created by B. Kampa (2006)
kampa@hifo.uzh.ch

20110406 mod/cad.mod integration method changed to derivimplicit as
suggested by Ted: http://www.neuron.yale.edu/phpBB/viewtopic.php?f=28&t=592

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