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Thalamic transformation of pallidal input (Hadipour-Niktarash 2006)
Accession: 111870
"In Parkinson’s disease, neurons of the internal segment of the globus pallidus (GPi) display the low-frequency tremor-related oscillations. These oscillatory activities are transmitted to the thalamic relay nuclei. Computer models of the interacting thalamocortical (TC) and thalamic reticular (RE) neurons were used to explore how the TC-RE network processes the low-frequency oscillations of the GPi neurons. ..."
Reference: Hadipour-Niktarash A (2006) A computational model of how an interaction between the thalamocortical and thalamic reticular neurons transforms the low-frequency oscillations of the globus pallidus. J Comput Neurosci 20:299-320 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type:  Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:  Thalamus;
Cell Type(s):  Thalamic relay neuron; Thalamic reticular neuron;  
Channel(s):  I Na,t; I T low threshold; I K; I h; I Potassium;  
Gap Junctions:  
Receptor(s):  GabaA; GabaB; AMPA;
Gene(s):  
Transmitter(s):  
Simulation Environment:  MATLAB;
Model Concept(s):  Parkinson's;
Implementer(s):  Hadipour-Niktarash, Arash [arash.hadipour at gmail.com];
Search NeuronDB for information about:  Thalamic relay neuron; Thalamic reticular neuron; GabaA; GabaB; AMPA; I Na,t; I T low threshold; I K; I h; I Potassium;
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Hadipour-Niktarash2006
readme.html
screenshot.jpg
TCRE.m
TCTR.m
                            
This is the readme for the model associated with

Hadipour-Niktarash A (2006) A computational model of how an
interaction between the thalamocortical and thalamic reticular neurons
transforms the low-frequency oscillations of the globus pallidus. J
Comput Neurosci 20:299-320

This model was supplied by the author.

Usage: Download and extract the archive.  Start matlab and cd to the
folder created during the expansion of the archive.  Add that folder
to the path (use addpath('c:\the actual path')).  Start the simulation
by typing TCRE and enter.  After a few minutes a figure similar to
Fig 1a2 of the paper appears:

screenshot

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