NEURON mod files from the paper:
Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA (2008) Functional
significance of axonal Kv7 channels in hippocampal pyramidal
neurons. Proc Natl Acad Sci U S A 105(22):7869-7874
In this paper, the model confirmed the experimental findings
suggesting that axonal Kv7 channels are critically and uniquely
required for determining the inherent spontaneous firing of
hippocampal CA1 pyramids, independently of alterations in synaptic
activity. This action was primarily due to modulation of action
potential threshold and membrane potential (RMP), amplified by control
of intrinsic axosomatic membrane properties. The model predicts that
the axonal Kv7 density could be 3-5 times that at the soma.
The fig4a.hoc reproduces the traces shown in Fig.4a of the paper.
Under linux/unix systems:
to compile the mod files use the command
and run the simulation hoc file with the command
Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
will open the simulation window.
Under MAC OS X:
to compile the mod files drag and drop the extracted folder onto the
mknrndll icon. Drag and drop the mosinit.hoc file onto the nrngui
Once the model is running you can click on a button, for example,
fig. 4(ii) leads to:
Questions on how to use this model
should be directed to email@example.com
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