ModelDB: Axonal Projection and Interneuron Types (Helmstaedter et al. 2008)

Axonal Projection and Interneuron Types (Helmstaedter et al. 2008)

Accession: 116053

"Interneurons in layer 2/3 (L2/3) of the somatosensory cortex show 4 types of axonal projection patterns with reference to the laminae and borders of columns in rat barrel cortex (Helmstaedter et al. 2008a). Here, we analyzed the dendritic geometry and electrical excitability of these interneurons. ... We conclude that 1) dendritic polarity is correlated to intrinsic electrical excitability, and 2) the axonal projection pattern represents an independent classifier of interneurons. "
References:
1. Helmstaedter M, Sakmann B, Feldmeyer D (2009) The Relation between Dendritic Geometry, Electrical Excitability, and Axonal Projections of L2-3 Interneurons in Rat Barrel Cortex. Cereb Cortex 19:938-950 [PubMed]
2. Helmstaedter M, Sakmann B, Feldmeyer D (2008) Neuronal Correlates of Local, Lateral, and Translaminar Inhibition with Reference to Cortical Columns. Cereb Cortex [PubMed]
3. Helmstaedter M, Sakmann B, Feldmeyer D (2008) L2/3 Interneuron Groups Defined by Multiparameter Analysis of Axonal Projection, Dendritic Geometry, and Electrical Excitability. Cereb Cortex [PubMed]
4. Helmstaedter M, Staiger JF, Sakmann B, Feldmeyer D (2008) Efficient recruitment of layer 2-3 interneurons by layer 4 input in single columns of rat somatosensory cortex. J Neurosci 28:8273-84 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Neocortex;
Cell Type(s):
Channel(s):	I Na,t; I L high threshold; I K; I M; I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron (web link to model);
Model Concept(s):	Influence of Dendritic Geometry;
Implementer(s):

Search NeuronDB for information about: I Na,t; I L high threshold; I K; I M; I K,Ca;

Model files (located externally to ModelDB) Help downloading and running models

helmstaedter et al., 2008. l2/3 interneurons in rat barrel cortex.

Note from the ModelDB Administrator: This page (below) is a copy of the web page http://www.mpimf-heidelberg.mpg.de/~mhelmsta/interneurons made on October 17th 2008.

L2/3 interneurons

This page provides supplementary material for the following studies:

Helmstaedter M, Sakmann B, Feldmeyer D (2008a) Neuronal Correlates of Local, Lateral and Translaminar Inhibition with Reference to Cortical Columns. Cerebral Cortex doi:10.1093/cercor/bhn141
Helmstaedter M, Sakmann B, Feldmeyer D (2008b) The relation between dendritic geometry, electrical excitability, and axonal projections of L2/3 interneurons in rat barrel cortex. Cerebral Cortex doi:10.1093/cercor/bhn138
Helmstaedter M, Sakmann B, Feldmeyer D (2008c) L2/3 interneuron groups defined by multiparameter analysis of axonal projection, dendritic geometry and electrical excitability. Cerebral Cortex doi:10.1093/cercor/bhn130
Helmstaedter M, Staiger JF, Sakmann B, Feldmeyer D (2008d) Efficient recruitment of layer 2/3 interneurons by layer 4 input in single columns of rat somatosensory cortex. The Journal of Neuroscience 28(33):8273–8284

Supplementary Material

Helmstaedter et al., 2008a,b: Reconstructions of L2/3 interneurons (.asc files):
Dendrites and Axons (n=51) 7.3MB| Dendrites (n=57) 1.2MB| L2/3 pyramidal neurons as control (n=4) 0.3MB
Helmstaedter et al., 2008b: Numerical model of firing patterns in L2/3 interneurons:
All Model Data (1MB)| README.pdf (40KB)
Rembrandt II software (for Igor PRO). A more user-friendly version of this software is currently developed for MATLAB and will be posted here upon completion.

For questions, suggestions, comments please contact moritz.helmstaedter@mpimf-heidelberg.mpg.de.

Last modified 2008/10/15 mh.

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