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A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)
Accession: 116575
The leech C-interneuron and its electrical synapse with the S-interneuron exhibit unusual properties: an asymmetric delay when impulses travel from one soma to the other, and graded C-interneuron impulse amplitudes under elevated divalent cation concentrations. These properties have been simulated using a SNNAP model in which the C-interneuron has multiple, independent spike initiation zones associated with individual electrical junctions with the C-interneuron.
Reference: Crisp KM (2009) Multiple spike initiation zones in a neuron implicated in learning in the leech: a computational model. Invert Neurosci 9:1-10 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type:  Neuron or other electrically excitable cell;
Brain Region(s)/Organism:  
Cell Type(s):   Leech C interneuron;
Channel(s):  I Na,p; I K; I K,leak; I K,Ca; I Sodium; I Calcium;  
Gap Junctions:  Gap junctions;
Receptor(s):  
Gene(s):  
Transmitter(s):  Glutamate;
Simulation Environment:  SNNAP;
Model Concept(s):  Action Potential Initiation; Action Potentials;
Implementer(s):  Crisp, Kevin [crisp at stolaf.edu];
Search NeuronDB for information about:  I Na,p; I K; I K,leak; I K,Ca; I Sodium; I Calcium; Glutamate;
\
Crisp2009
readme.html
screenshot.jpg
1.8mM_divalents.sm
1.8mM_Na.vdg
25mM_ADP.vdg
25mM_Ca.vdg
25mM_divalents.sm
25mM_Na.vdg
ADP.m
ADP.vdg
alpha.fAt
AxonalRes.es
C.neu
C1234.neu
C1a.neu
C1a_leak.R
C1a_leak.vdg
C1b_leak.R
C1b_leak.vdg
C1c_leak.R
C1c_leak.vdg
C1d.neu
C1d_leak.R
C1d_leak.vdg
C2a.neu
C3a.neu
C4a.neu
C4a_leak.R
C4a_leak.vdg
C4b.neu
C4b_leak.R
C4b_leak.vdg
C4c.neu
C4c_leak.R
C4c_leak.vdg
C4d.neu
C4d_leak.R
C4d_leak.vdg
Ca.fBR
Ca.ion
Ca.ion.tmp
Ca.m
Ca.vdg
CCellModel.ntw
divalents.fBR
divalents.sm
divalents.tr
divalentsCa.fBR
fAHP.m
fAHP.vdg
Figure2.smu
Figure2.smu.exec
Figure2.smu.hmn
Figure2.smu.ing
Figure2.smu.out.head
glutamate.cs
Kdr.m
Kdr.vdg
leak.R
leak.vdg
leakC1a.R
leak_pas.vdg
mAHP.A
mAHP.vdg
Na.h
Na.m
Na.vdg
netwf
netwfile
new.R
new.r.tmp
new2.R
new2.R.tmp
ousgrf.def
pleak.vdg
R.neu
r.r
R1.neu
1.8mM_ADP.vdg
S.neu
S123.neu
Sabcd.neu
SC.es
1.8mM_Ca.vdg
simufiles.usd
SNNAP_CCell.bas
Stim_S_Rec_C.ous
Stim_S_Rec_C.ous.mnu
Stim_S_Rec_C.trt
Stim_S_Stim_C.ous
Stim_S_Stim_C.ous.mnu
Stim_S_Stim_C.trt
S_ExcitableNeurite_1.8mM.neu
vbas31w.sll
vgui31w.sll
voflr31w.sll
                            
This is the model for the paper

Crisp KM (2009) Multiple spike initiation zones in a neuron implicated
in learning in the leech: a computational model. Invert Neurosci

Usage:

Make sure you have SNNAP installed and started according to the
instructions at http://snnap.uth.tmc.edu/content/downloads.htm

After you load the simulation and press start you should see figure 2
reproduced:

screenshot

These model files were supplied by Dr Kevin Crisp.

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