ModelDB: Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)

Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)

Accession: 116606

"Biophysical properties of neurons contributing to the ability of an animal to decide whether or not to respond were examined. B31/B32, two pairs of bilaterally symmetrical Aplysia neurons, are major participants in deciding to initiate a buccal motor program, the neural correlate of a consummatory feeding response. B31/B32 respond to an adequate stimulus after a delay, during which time additional stimuli influence the decision to respond. B31/B32 then respond with a ramp depolarization followed by a sustained soma depolarization and axon spiking that is the expression of a commitment to respond to food. Four currents contributing to decision making in B31/B32 were characterized, and their functional effects were determined, in current- and voltage-clamp experiments and with simulations. ... Hodgkin-Huxley kinetic analyses were performed on the outward currents. Simulations using equations from these analyses showed that IK-V and IK-A slow the ramp depolarization preceding the sustained depolarization. The three outward currents contribute to braking the B31/B32 depolarization and keeping the sustained depolarization at a constant voltage. The currents identified are sufficient to explain the properties of B31/B32 that play a role in generating the decision to feed."
Reference: Hurwitz I, Ophir A, Korngreen A, Koester J, Susswein AJ (2008) Currents contributing to decision making in neurons B31-B32 of Aplysia. J Neurophysiol 99:814-30 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Aplysia;
Cell Type(s):	Aplysia B31/B32 neuron;
Channel(s):	I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	SNNAP;
Model Concept(s):	Action Selection/Decision Making;
Implementer(s):

Search NeuronDB for information about: I Na,t; I A; I K;

Model files

Help downloading and running models

hurwitzEtAl2008

with_all_currents_fast_stimulus

with_all_currents_slow_stimulus

readme.html

screenshot1.JPG

screenshot2.JPG

This is the readme for the model associated with the paper:

Hurwitz I, Ophir A, Korngreen A, Koester J, Susswein AJ (2008)
Currents contributing to decision making in neurons B31-B32 of
Aplysia.  J Neurophysiol 99:814-30

This zip file contains two directories. These are the directories that
will reproduce the voltage traces in Figs. 11 and 12 of the above
paper. Only the upper of the two traces produced when the files are
run are relevant. The top traces show soma recordings, which are in
the paper. The bottom traces show axon recordings, which were not
included in the paper. The files describing the parameters of the
cells are identical in the two directories. The only difference is the
file producing the injected current.

Usage:

Make sure you have SNNAP installed and started according to the
instructions at http://snnap.uth.tmc.edu/content/downloads.htm

After you load the fast simulation and press start you should see
Fig. 11 reproduced:



After you load the fast simulation and press start you should see
Fig. 12 reproduced:



These model files were supplied by Dr Avy Susswein.

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