ModelDB: High frequency stimulation of the Subthalamic Nucleus (Rubin and Terman 2004)

High frequency stimulation of the Subthalamic Nucleus (Rubin and Terman 2004)

Accession: 116867

" ... Using a computational model, this paper considers the hypothesis that DBS works by replacing pathologically rhythmic basal ganglia output with tonic, high frequency firing. In our simulations of parkinsonian conditions, rhythmic inhibition from GPi to the thalamus compromises the ability of thalamocortical relay (TC) cells to respond to depolarizing inputs, such as sensorimotor signals. High frequency stimulation of STN regularizes GPi firing, and this restores TC responsiveness, despite the increased frequency and amplitude of GPi inhibition to thalamus that result. We provide a mathematical phase plane analysis of the mechanisms that determine TC relay capabilities in normal, parkinsonian, and DBS states in a reduced model. This analysis highlights the differences in deinactivation of the low-threshold calcium T -current that we observe in TC cells in these different conditions. ..."
Reference: Rubin JE, Terman D (2004) High frequency stimulation of the subthalamic nucleus eliminates pathological thalamic rhythmicity in a computational model. J Comput Neurosci 16:211-35 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Thalamus; Basal ganglia; Subthalamic Nucleus;
Cell Type(s):	Thalamic relay neuron; Subthalamic projection neuron; Globus pallidus neuron;
Channel(s):	I Na,t; I T low threshold; I K; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	XPP;
Model Concept(s):	Activity Patterns; Parkinson's; Deep brain stimulation;
Implementer(s):

Search NeuronDB for information about: Thalamic relay neuron; I Na,t; I T low threshold; I K; I Calcium;

Model files

Help downloading and running models

rubin_terman2004

readme.html

screenshot.jpg

rubin_terman_dbs.ode.set

rubin_terman_pd.ode

rubin_terman_pd.ode.setnorm

rubin_terman_pd.ode.setpark

rubin_terman_dbs.ode

These are the model files for the paper:

Rubin JE, Terman D (2004) High frequency stimulation of the
subthalamic nucleus eliminates pathological thalamic rhythmicity in a
computational model. J Comput Neurosci 16:211-35

These model files were supplied by Jonathan Rubin.

Example use:

Make sure you have xpp installed
(http://www.math.pitt.edu/~bard/xpp/xpp.html) and start with a command
(linux, although mac and windows xpp versions are available)

xppaut rubin_terman_pd.ode

Select File -> Read and choose rubin_terman_pd.ode.setnorm or
rubin_terman_pd.ode.setpark for normal/PD

Select InitialConds -> Go

and you should see a figure created similar to fig 5 C, D from the
paper:

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