ModelDB: Rat α7 nAChR desensitization is modulated by W55 (Gay et al. 2008)

Rat α7 nAChR desensitization is modulated by W55 (Gay et al. 2008)

Accession: 117508

"The rat alpha7 nicotinic acetylcholine receptor (nAChR) can undergo rapid onset of desensitization; however, the mechanisms of desensitization are largely unknown. The contribution of a tryptophan (W) residue at position 55 of the rat alpha7 nAChR subunit, which lies within the beta2 strand, was studied by mutating it to other hydrophobic and/or aromatic amino acids, followed by voltage-clamp experiments in Xenopus oocytes. When mutated to alanine, the alpha7-W55A nAChR desensitized more slowly, and recovered from desensitization more rapidly, than wildtype alpha7 nAChRs. The contribution of desensitization was validated by kinetic modelling. ..."
Reference: Gay EA, Giniatullin R, Skorinkin A, Yakel JL (2008) Aromatic residues at position 55 of rat alpha7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitization. J Physiol 586:1105-15 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):	Nicotinic;
Gene(s):	nAChR alpha 7;
Transmitter(s):
Simulation Environment:	Pascal/Delphi;
Model Concept(s):	Ion Channel Kinetics;
Implementer(s):	Skorinkin, Andrei [askorink at yandex.ru];

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Model files

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These are the Delphi source files for the paper:

Gay EA, Giniatullin R, Skorinkin A, Yakel JL. Aromatic residues at
position 55 of rat alpha7 nicotinic acetylcholine receptors are
critical for maintaining rapid desensitization.  

J Physiol. 2008 Feb 15;586(4):1105-15. Epub 2007 Dec 20.
PMID: 18096596

These files were supplied by Dr Andrey Skorinkin.

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