| Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005) |
| Accession: 119266 |
"We use a multi-compartmental model of a CA1 pyramidal cell to study changes in hippocampal excitability that result from aging-induced alterations in calcium-dependent membrane mechanisms.
The model incorporates N- and L-type calcium channels which are respectively coupled to fast and slow afterhyperpolarization potassium channels.
Model parameters are calibrated using physiological data.
Computer simulations reproduce the decreased excitability of aged CA1 cells, which results from increased internal calcium accumulation, subsequently larger postburst slow afterhyperpolarization, and enhanced spike frequency adaptation.
We find that aging-induced alterations in CA1 excitability can be modelled with simple coupling mechanisms that selectively link specific types of calcium channels to specific calcium-dependent potassium channels."
Reference: Markaki M, Orphanoudakis S, Poirazi P (2005) Modelling reduced excitability in aged CA1
neurons as a calcium-dependent process Neurocomputing 65-66:305-314 |
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This is the readme for the model from the paper
Markaki M, Orphanoudakis S, Poirazi P (2005) Modelling reduced
excitability in aged CA1 neurons as a calcium-dependent process
Neurocomputing 65-66:305-314
These model files were supplied by Dr Poirazi.
The model files were changed slightly after the paper however they
reproduce the traces in Figure 3.
Usage
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Auto-launch from ModelDB or download and extract the archive and then
unix/linux
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Compile the mod files with "nrnivmodl mechanism" , then start with
"nrngui mosinit.hoc"
mswin
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Compile the mod files with mknrndll. Move the nrnmech.dll up one
level to the top level directory. Double click on mosinit.hoc in a
windows explorer.
Once the simulation has started press the run button to generate
figures similar to the traces in Figure 2 (increased Ca2+):
20120201 cadL.mod cad.mod cadN.mod updated to derivimplicit as per
http://www.neuron.yale.edu/phpBB/viewtopic.php?f=28&t=592
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