ModelDB: Electrically-coupled Retzius neurons (Vazquez et al. 2009)

Electrically-coupled Retzius neurons (Vazquez et al. 2009)

Accession: 120910

"Dendritic electrical coupling increases the number of effective synaptic inputs onto neurons by allowing the direct spread of synaptic potentials from one neuron to another. Here we studied the summation of excitatory postsynaptic potentials (EPSPs) produced locally and arriving from the coupled neuron (transjunctional) in pairs of electrically-coupled Retzius neurons of the leech. We combined paired recordings of EPSPs, the production of artificial EPSPs (APSPs) in neuron pairs with different coupling coefficients and simulations of EPSPs produced in the coupled dendrites. ..."
Reference: Vazquez Y, Mendez B, Trueta C, De-Miguel FF (2009) Summation of Excitatory Postsynaptic Potentials in Electrically-Coupled Neurons. Neuroscience [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Leech;
Cell Type(s):	Leech Retzius neuron;
Channel(s):	I Na,t; I A; I K; I K,Ca; I Calcium;
Gap Junctions:	Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Synaptic Integration;
Implementer(s):

Search NeuronDB for information about: I Na,t; I A; I K; I K,Ca; I Calcium;

Model files

Help downloading and running models

ElectricallycoupledRetziusneurons

This is the readme for the model associated with the paper

Vazquez Y, Mendez B, Trueta C, De-Miguel FF (2009) Summation of
Excitatory Postsynaptic Potentials in Electrically-Coupled
Neurons. Neuroscience

These model files were supplied by Dr De-Miguel.

Demo:

Either auto-launch from ModelDB or download and extract the zip
archive.  Then under

mswin:
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Compile the mod files with mknrndll, then double click on mosinit.hoc

linux/unix:
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Compile the mod files with nrnivmodl.  Then type "nrngui mosinit.hoc".

Mac OS X:
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Drag and drop the newly created folder onto the mknrndll icon.  Drag
and drop the mosinit.hoc file onto the nrngui icon.

Once the simulation has started:
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Press Init & Run and you should see a picture similar to:

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