ModelDB: Complex CA1-neuron to study AP initiation (Wimmer et al. 2010)

Complex CA1-neuron to study AP initiation (Wimmer et al. 2010)

Accession: 123927

Complex model of a pyramidal CA1-neuron, adapted from Royeck, M., et al. Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. Journal of neurophysiology 100, 2361-2380 (2008). It contains a biophysically realistic morphology comprising 265 compartments (829 segments) and 15 different distributed Ca2+- and/or voltage-dependent conductances.
Reference: Wimmer VC, Reid CA, Mitchell S, Richards KL, Scaf BB, Leaw BT, Hill EL, Royeck M, Horstmann M (2010) Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. J Clin Invest 120:2661-71 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	CA1 pyramidal neuron;
Channel(s):	I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I p,q; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):	Nav SCN1B;
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Action Potential Initiation; Detailed Neuronal Models; Epilepsy;
Implementer(s):	Horstmann, Marie-Therese [mhorstma at uni-bonn.de];

Search NeuronDB for information about: CA1 pyramidal neuron; I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I p,q; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium;

Model files

Help downloading and running models

this is the readme for the model associated with the paper:

Wimmer VC, Reid CA, Mitchell S, Richards KL, Scaf BB, Leaw BT, Hill
EL, Royeck M, Horstmann M (2010) Axon initial segment dysfunction in a
mouse model of genetic epilepsy with febrile seizures plus.
J Clin Invest 120:2661-71

These model files were supplied  by Marie-Therese Horstmann.

Usage:
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Check that you have NEURON installed (available from
http://www.neuron.yale.edu). Autolaunch from ModelDB **or** download
and extract the archive and compile the mod files to run under ...

linux/unix
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by typing
nrnivmodl
in the top level directory.  Then type
nrngui mosinit.hoc

mswin
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Run mknrndll, cd to the expanded directory and press make nrnmech.dll
button.  Double click on the mosinit.hoc file.

MAC OS X
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Drag and drop the expanded folder onto mknrndll icon in the NEURON
application folder. Drag and drop the mosinit.hoc file onto the nrngui
icon to start the simulation.

Once the simulation is running:
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Choose one of the first two buttons to either run a demo version (low
resolution) of figure 7A or a publication quality run. You can also
change the model parameters varied in the publication above.

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