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Computer model of clonazepam`s effect in thalamic slice (Lytton 1997)
Accession: 12631
Demonstration of the effect of a minor pharmacological synaptic change at the network level. Clonazepam, a benzodiazepine, enhances inhibition but is paradoxically useful for certain types of seizures. This simulation shows how inhibition of inhibitory cells (the RE cells) produces this counter-intuitive effect.
Reference: Lytton WW (1997) Computer model of clonazepam's effect in thalamic slice. Neuroreport 8:3339-43 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type:  Network;
Brain Region(s)/Organism:  Thalamus;
Cell Type(s):  Thalamic relay neuron; Thalamic reticular neuron;  
Channel(s):  I Na,t; I T low threshold; I K; I CAN;  
Gap Junctions:  
Receptor(s):  GabaA; Gaba;
Gene(s):  
Transmitter(s):  Gaba;
Simulation Environment:  Neuron;
Model Concept(s):  Activity Patterns; Bursting; Therapeutics; Epilepsy; Calcium dynamics;
Implementer(s):  Lytton, William ;
Search NeuronDB for information about:  Thalamic relay neuron; Thalamic reticular neuron; Gaba; GabaA; I CAN; I K; I Na,t; I T low threshold; Gaba;
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lytton97b
README
Fig3.gif
Fig4.gif
calciumpump_destexhe.mod
GABAA.mod
GABAB1.mod
GABALOW.mod
HH_traub.mod
IAHP_destexhe.mod
ICAN_destexhe.mod
Ih_old.mod
IT2_huguenard.mod
IT_wang.mod
NMDA.mod
pregen.mod
presyn.mod
pulse.mod
rand.mod
AMPA.mod
declist.hoc
decvec.hoc
default.hoc
init.hoc
disp.hoc
labels.hoc
local.hoc
mosinit.hoc
network.hoc
boxes.hoc
nrnoc.hoc
params.hoc
geom.hoc
grvec.hoc
run.hoc
show.hoc
simctrl.hoc
snscode.hoc
snsgr.hoc
queue.inc
mod_func.c
czpnew.dat
bg.inc
ctl.dat
presyn.inc
sns.inc
snsarr.inc
ctlnew.dat
czp.dat
snshead.inc
synq.inc
xtmp
                            
// $Id: simctrl.hoc,v 1.14 2000/11/27 21:59:33 billl Exp $
// Graphic routines for neuremacs simulation control

proc sim_panel () {
  xpanel(simname)
        xvarlabel(output_file)
	xbutton("Init", "stdinit()")
	xbutton("Init & Run", "run()")
	xbutton("Stop", "stoprun=1")
	xbutton("Continue till Tstop", "continueRun(tstop)")
	xvalue("Continue till", "runStopAt", 1, "{continueRun(runStopAt) stoprun=1}", 1, 1)
	xvalue("Continue for", "runStopIn", 1, "{continueRun(t + runStopIn) stoprun=1}", 1,1)
	xbutton("Single Step", "steprun()")
	xvalue("Tstop", "tstop", 1, "tstop_changed()", 0, 1)
	graphmenu()
	sim_menu_bar()
	misc_menu_bar()
  xpanel()
}

proc misc_menu_bar() {
  xmenu("Miscellaneous")
    xbutton("Label Graphs", "labelgrs()")
    xbutton("Label With String", "labelwith()")
    xbutton("Label Panel", "labelpanel()")
	xbutton("Parameterized Function", "load_template(\"FunctionFitter\") makefitter()")
  xmenu()
}

proc sim_menu_bar() {
  xmenu("Simulation Control")
    xbutton("File Vers", "elisp(\"sim-current-files\")")
    xbutton("File Status...", "elisp(\"sim-rcs-status\")")
    xbutton("Sim Status", "elisp(\"sim-portrait\")")
    xbutton("Load Current Files", "elisp(\"sim-load-sim\")")
    xbutton("Load Templates", "elisp(\"sim-load-templates\")") 
    xbutton("Load File...", "elisp(\"sim-load-file\")") 
    xbutton("Save Sim...", "elisp(\"sim-save-sim\")")
    xbutton("Set File Vers...", "elisp(\"sim-set-file-ver\")")
    xbutton("Read Current Vers From Index", "elisp(\"sim-read-index-file\")")
    xbutton("Read Last Saved Vers", "elisp(\"sim-read-recent-versions\")")
    xbutton("Output to sim buffer", "elisp(\"sim-direct-output\")")
  xmenu()
}

proc labelpanel() {
  xpanel(simname,1)
	xvarlabel(output_file)
  xpanel()
}

proc labels () {
  labelwith($s1)
  labelgrs()
}

proc labelgrs () { local i, j, cnt
  for j=0,n_graph_lists-1 {
    cnt = graphList[j].count() - 1
    for i=0,cnt labelgr(graphList[j].object(i))
  }
}

proc labelwith () { local i, j, cnt
  temp_string_ = user_string_  // save the old one
  if (numarg() == 1) { /* interactive mode */  
    user_string_ = $s1
  } else {
    string_dialog("write what?", user_string_)
  }
  for j=0,n_graph_lists-1 {
    cnt = graphList[j].count() - 1
    for i=0,cnt {
      graphList[j].object(i).color(0)
      graphList[j].object(i).label(0.5,0.9,temp_string_)
      graphList[j].object(i).color(1)
      graphList[j].object(i).label(0.5,0.9,user_string_)
    }
  }
}

proc labelgr () { local i
  $o1.color(0)  // white overwrite
  for (i=0;i<10;i=i+1) { // erase every possible runnum for this date
    sprint(temp_string_,"%s %d%d",datestr,i,i)
    $o1.label(0.1,0.7,temp_string_) }
  $o1.color(1) // back to basic black
  sprint(temp_string_,"%s %02d",datestr,runnum)
  $o1.label(0.1,0.7,temp_string_)
}



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