ModelDB: CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010)

CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010)

Accession: 126776

The model demonstrates that CA1 pyramidal neurons support rebound spikes mediated by hyperpolarization-activated inward current (Ih), and normally masked by A-type potassium channels (KA). Partial KA reduction confined to one or few branches of the apical tuft may be sufficient to elicit a local spike following a train of synaptic inhibition. These data suggest that the plastic regulation of KA can provide a dynamic switch to unmask post-inhibitory spiking in CA1 pyramidal neurons, further increasing the signal processing power of the CA1 synaptic microcircuitry.
Reference: Ascoli GA, Gasparini S, Medinilla V, Migliore M (2010) Local Control of Post-Inhibitory Rebound Spiking in CA1 Pyramidal Neuron Dendrites J.Neurosci. 30(18):6434-42 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Dendrite;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	CA1 pyramidal neuron;
Channel(s):	I Na,t; I A; I h; I Potassium;
Gap Junctions:
Receptor(s):	Gaba;
Gene(s):
Transmitter(s):	Gaba;
Simulation Environment:	Neuron;
Model Concept(s):	Action Potential Initiation; Activity Patterns; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Action Potentials; Synaptic modulation of active currents; Synaptic Integration;
Implementer(s):	Migliore, Michele [Michele.Migliore at Yale.edu];

Search NeuronDB for information about: CA1 pyramidal neuron; Gaba; I Na,t; I A; I h; I Potassium; Gaba;

Model files

Help downloading and running models

NEURON mod files from the paper:

Local Control of Post-Inhibitory Rebound Spiking in CA1 Pyramidal
Neuron Dendrites Giorgio A. Ascoli, Sonia Gasparini, Virginia
Medinilla, Michele Migliore, J.Neurosci. in press, 2010.

The simulation file rebound.hoc reproduces the simulations shown in
Fig. 2d of the paper.

Questions on how to use this model
should be directed to michele.migliore@pa.ibf.cnr.it

Usage:

Auto-launch from ModelDB or download and extract this archive and then
compile the mod files.  Start under windows by double-clicking the
mosinit.hoc file, under linux/unix by typing "nrngui mosinit.hoc", and
under mac OS X by dragging and dropping mosinit.hoc on the nrngui
icon.

Once the simulation is started press the buttons to run the model
under the different conditions shown in figure 2d:

Control:


4-AP:


4-AP + ZD:

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