ModelDB: A two-stage model of dendritic integration in CA1 pyramidal neurons (Katz et al. 2009)

A two-stage model of dendritic integration in CA1 pyramidal neurons (Katz et al. 2009)

Accession: 127351

"... In a two-stage integration model, inputs contribute directly to dendritic spikes, and outputs from multiple branches sum in the axon. ... We used serial-section electron microscopy to reconstruct individual apical oblique dendritic branches of CA1 pyramidal neurons and observe a synapse distribution consistent with the two-stage integration model. Computational modeling suggests that the observed synapse distribution enhances the contribution of each dendritic branch to neuronal output."
Reference: Katz Y, Menon V, Nicholson DA, Geinisman Y, Kath WL, Spruston N (2009) Synapse distribution suggests a two-stage model of dendritic integration in CA1 pyramidal neurons. Neuron 63:171-7 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	CA1 pyramidal neuron;
Channel(s):	I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron (web link to model);
Model Concept(s):	Synaptic Integration;
Implementer(s):

Search NeuronDB for information about: CA1 pyramidal neuron; I Na,t; I A; I K;

Model files (located externally to ModelDB) Help downloading and running models

note from the modeldb administrator: the below is a copy of the webpage from the Spruston Lab where the NEURON model is available.

2-Stage Integration

Code that accompanies the Spruston Lab's July 2009 Neuron paper (Katz et. al)

Download 2-Stage-Code

(image attribution: Dan Nicholson)

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