| Mathematical model for windup (Aguiar et al. 2010) |
| Accession: 128559 |
"Windup is characterized as a frequency-dependent
increase in the number of evoked action potentials in dorsal
horn neurons in response to electrical stimulation of afferent C-fibers.
...
The approach presented here relies on mathematical and
computational analysis to study the mechanism(s) underlying windup.
From experimentally obtained windup profiles, we extract the time
scale of the facilitation mechanisms that may support the characteristics
of windup.
Guided by these values and using simulations of a
biologically realistic compartmental model of a wide dynamic range
(WDR) neuron, we are able to assess the contribution of each
mechanism for the generation of action potentials windup.
..."
Reference: Aguiar P, Sousa M, Lima D (2010) NMDA channels together with L-type calcium currents and calcium-activated nonspecific cationic currents are sufficient to generate windup in WDR neurons. J Neurophysiol 104:1155-66 [PubMed] |
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| this is the readme for the model associated with
Aguiar P, Sousa M, Lima D (2010) NMDA channels together with L-type
calcium currents and calcium-activated nonspecific cationic currents
are sufficient to generate windup in WDR neurons. J Neurophysiol
104:1155-66
This model is also available as a web link through the paper:
http://www.fc.up.pt/pessoas/pauloaguiar/WDRmodel.zip
You can either auto-launch the model or download the zip file, expand
compile the mod files, and run mosinit.hoc to regenerate figure 2C:
20120330 CaIntraCellDyn.mod had it's solve method updated from euler
to derivimplicit. For more information see:
http://www.neuron.yale.edu/phpBB/viewtopic.php?f=28&t=592
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