ModelDB: Shaping of action potentials by different types of BK channels (Jaffe et al., 2011)

Shaping of action potentials by different types of BK channels (Jaffe et al., 2011)

Accession: 140471

Dentate gyrus granule cells highly express the beta4 accessory subunit which confer BK channels with type II properties. The properties of heterologously-expressed BK channels (with and without the beta4 subunit) were used to construct channel models. These were then used to study how they affect single action potentials and trains of spikes in a model dentate gyrus granule cells (based on Aradi and Holmes, 1999).
Reference: Jaffe DB, Wang B, Brenner R (2011) Shaping of action potentials by type I and type II large-conductance Ca(2+)-activated K(+) channels. Neuroscience [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Dentate granule cell;
Channel(s):	I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Action Potentials;
Implementer(s):	Jaffe, David B [david.jaffe at utsa.edu];

Search NeuronDB for information about: Dentate granule cell; I K,Ca;

Model files

Help downloading and running models

Files for reproducing Figure 5 from Jaffe, Wang, and Brenner (2011)
using NEURON (http://www.neuron.yale.edu).

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Hoc code:

figure5.hoc	- hoc script to run simulation
channels.ses	- descriptions of Na and KDR channels (Aradi and Holmes, 1999)
varybeta.parm 	- Systematic variation of the coeffecient 'S' 

mod files for producing the 'special' executable:

aabBK.mod     - alphabeta4 and alpha BK channel descriptions
Ca.mod	      - calcium channel descriptions (Aradi and Holmes, 1999)

IgorPro (using ver 5.02) 

Figure5plots.pxp   - IgorPro packed experiment

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Output file convention: trace_BKchannelType_run.dat

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