NEURON files from the paper:
Migliore M, Migliore R (2012) Know Your Current Ih: Interaction with a
Shunting Current Explains the Puzzling Effects of Its Pharmacological
or Pathological Modulations. PLoS ONE 7(5): e36867.
The non-specific, hyperpolarization activated, Ih current is
particularly involved in epilepsy and it exhibits an excitatory or
inhibitory action on synaptic integration in an apparently
inconsistent way. With a series of simulations, using a realistic
model, we show how and why a shunting current, such as that carried by
TASK-like channels, dependent on the Ih peak conductance, is able to
explain virtually all experimental findings on Ih up- or
down-regulation by modulators or pathological conditions.
The hoc file " fig-5a" is a typical simulation file, for illustration
purposes only, that reproduces the results reported in Fig. 5a:
It tests the peak somatic membrane potential as a function of synaptic
stimulation strength using I_lk with lk = 0.7 (i.e. 70% of the peak Ih
conductance) under control conditions (red) and no Ih (blue). Ih
increases the peak depolarization for weak inputs and reduces it for
Under unix systems:
to compile the mod files use the command
and run the simulation hoc file with the command
Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
will open the simulation window.
Questions on how to use this model should be directed to
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