| Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000) |
| Accession: 34558 |
It has been found that in cultured Aplysia neurons bath applications of 40 mM cafffeine evokes oscillations of the membrane potential with about a 40 mV amplitude with a frequency of 0.2 to 0.5 Hz. The most probable mechanism of these caffeine-induced oscillations is inhibition of voltage-activated outward potassium current and, as can be seen from our mathematical modeling, slowdown of inactivation of inward sodium current. It seems likely that these oscillations have a purely membrane origin. Please see paper for results and details.
Reference: Komendantov AO, Kononenko NI (2000) Caffeine-induced oscillations of the membrane potential in Aplysia Neurons. Neirofiziologiya/Neurophysiology 32:102-111 |
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| README_Komendantov.txt (or Readme.txt in ModelDB)
This simulation reproduces the model published
in:
Komendantov, A.O. and Kononenko, N.I. (2000)
Caffeine-induced oscillations of the membrane
potential in Aplysia neurons. Neurophysiology 32:
77-84.
The results of a simulation are illustrated in
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