ModelDB: Olfactory Mitral cell: AP initiation modes (Chen et al 2002)

Olfactory Mitral cell: AP initiation modes (Chen et al 2002)

Accession: 3793

The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational modeling to analyze action-potential initiation and propagation in the primary dendrite.
Reference: Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J (2002) Multiple Modes of Action-Potential Initiation and Propagation in Mitral Cell Primary Dendrite. J Neurophysiol 88:2755-64 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Olfactory bulb mitral cell; Myelinated neuron;
Channel(s):	I Na,t; I K;
Gap Junctions:
Receptor(s):	AMPA;
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Action Potential Initiation; Synaptic Integration;
Implementer(s):	Hines, Michael [Michael.Hines at Yale.edu];

Search NeuronDB for information about: Olfactory bulb mitral cell; AMPA; I Na,t; I K;

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Multiple Modes of Action Potential Initiation and Propagation in
Mitral Cell Primary Dendrite.
Wei R. Chen, Gongyu Y. Shen, Gordon M. Shepherd, Michael L. Hines, and
Jens Midtgaard.
Submitted to J. Neurophysiol. (2002)

The autolaunch example produces all figures as well as the fit to the
Shen 1999 data for high and low current stimulus in soma and primary
electrodes. Figures in the paper can also be generated by directly
launching:
	fig3a.hoc
	fig3b.hoc //long computation time unless variable step method used
	fig5a.hoc
	fig5b.hoc
	fig6.hoc

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