ModelDB: Dorsal root ganglion (DRG) neuronal model (Amir, Devor 2003)

Dorsal root ganglion (DRG) neuronal model (Amir, Devor 2003)

Accession: 51022

The model shows that an electrically excitable soma is not necessary for spike through-conduction in the t-shaped geometry of a dorsal root ganglion neuron axon. Electrical excitability of the soma is required, however, for soma spike invasion. See papers for details and more.
References:
1. Amir R, Devor M (2003a) Electrical excitability of the soma of sensory neurons is required for spike invasion of the soma, but not for through-conduction. Biophys J 84:2181-91 [PubMed]
2. Amir R, Devor M (2003b) Extra spike formation in sensory neurons and the disruption of afferent spike patterning. Biophys J 84:2700-8 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:
Brain Region(s)/Organism:
Cell Type(s):	Myelinated neuron; Dorsal Root Ganglion (DRG) neuron;
Channel(s):	I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Activity Patterns; Detailed Neuronal Models; Axonal Action Potentials; Action Potentials;
Implementer(s):	Amir, Ron [ronamir at pob.huji.ac.il];

Search NeuronDB for information about: I Na,t; I K;

Model files

Help downloading and running models

Readme.txt file for the model associated with the papers

Amir R, Devor M.
Electrical excitability of the soma of sensory neurons is required for 
spike invasion of the soma, but not for through-conduction.
Biophys J. 2003 Apr;84(4):2181-91. 

Amir R, Devor M.
Extra spike formation in sensory neurons and the disruption of afferent 
spike patterning.
Biophys J. 2003 Apr;84(4):2700-8.

Approximate versions of Figures 2 and 3 from the first paper are recreated
from the auto-launch in modeldb (requires NEURON installed).

Other usage:  download and expand the arhive (zip file) on your machine.
Use nrnivmodl (unix) or mknrndll (mswin or mac) to compile the mod file.
Then execute
nrngui mosinit.hoc
on the command line in unix or double click on the mosinit.hoc file
(mac or mswin).

ModelDB Home SenseLab Home Help
Questions, comments, problems? Email the ModelDB Administrator
How to cite ModelDB
This site is Copyright 2012 Shepherd Lab, Yale University