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Kv4.3, Kv1.4 encoded K channel in heart cells & tachy. (Winslow et al 1999, Greenstein et al 2000)
Accession: 62654
(1999) We present a model of the canine midmyocardial ventricular action potential and Ca2+ transient. The model is used to estimate the degree of functional upregulation and downregulation of Na/Ca exchanger protein and sarcoplasmic reticulum Ca ATPase in heart failure using data obtained from 2 different experimental protocols. (2000): A model of canine I:(to1) (the Ca(2+)-independent transient outward current) is formulated as the combination of Kv4.3 and Kv1.4 currents and is incorporated into an existing canine ventricular myocyte model. Simulations demonstrate strong coupling between L-type Ca(2+) current and I:(Kv4.3) and predict a bimodal relationship between I:(Kv4.3) density and APD whereby perturbations in I:(Kv4.3) density may produce either prolongation or shortening of APD, depending on baseline I:(to1) current level. See each paper for more and details.
References:
1. Greenstein JL, Wu R, Po S, Tomaselli GF, Winslow RL (2000) Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration. Circ Res 87:1026-33 [PubMed]
2. Winslow RL, Rice J, Jafri S, Marban E, O'Rourke B (1999) Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. Circ Res 84:571-86 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type:  Neuron or other electrically excitable cell;
Brain Region(s)/Organism:  
Cell Type(s):   
Channel(s):  I L high threshold; I A; I K; I Calcium; I Potassium;  
Gap Junctions:  
Receptor(s):  
Gene(s):  
Transmitter(s):  
Simulation Environment:  Java;
Model Concept(s):  Ion Channel Kinetics; Heart disease;
Implementer(s):  Bassingthwaighte, James; Li, Zheng ;
Search NeuronDB for information about:  I L high threshold; I A; I K; I Calcium; I Potassium;
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CCBM_weblink1
readme.html
winslowEtAl.jpg
                            
Readme.html for a web-link to the model code associated with the papers:

Ref 1: Raimond Winslow, et al,
Mechanisms of altered excitation-contraction coupling
in Canine Tachycardia-induced heart Failure, II
Circ Res, 84:571-586, 1999.

Ref 2: Joseph Greenstein et al., 
Role of the Calcium-independent transient outward current
Ito1 in shaping action potential morphology and duration
Circ Res, 1026-1033, 2000.

The java model code is available from 
http://nsr.bioeng.washington.edu/PLN/Members/garyr/electrophysiology/WinslowRiceJafriCanineVentricularCell.proj/view


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