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Pyramidal neuron coincidence detection tuned by dendritic branching pattern (Schaefer et al 2006)
Accession: 83344
"... We examined the relationship between dendritic arborization and the coupling between somatic and dendritic action potential (AP) initiation sites in layer 5 (L5) neocortical pyramidal neurons. Coupling was defined as the relative reduction in threshold for initiation of a dendritic calcium AP due to a coincident back-propagating AP. Simulations based on reconstructions of biocytin-filled cells showed that addition of oblique branches of the main apical dendrite in close proximity to the soma (d < 140 um) increases the coupling between the apical and axosomatic AP initiation zones, whereas incorporation of distal branches decreases coupling. ... We conclude that variation in dendritic arborization may be a key determinant of variability in coupling (49+-17%; range 19-83%; n = 37) and is likely to outweigh the contribution made by variations in active membrane properties. Thus coincidence detection of inputs arriving from different cortical layers is strongly regulated by differences in dendritic arborization."
Reference: Schaefer AT, Larkum ME, Sakmann B, Roth A (2003) Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern. J Neurophysiol 89:3143-54 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type:  Neuron or other electrically excitable cell;
Brain Region(s)/Organism:  
Cell Type(s):  Neocortical pyramidal neuron: deep;  
Channel(s):  I Na,t; I A; I K; I M; I K,Ca; I Calcium;  
Gap Junctions:  
Receptor(s):  
Gene(s):  
Transmitter(s):  
Simulation Environment:  Neuron; Neuron (web link to model);
Model Concept(s):  Action Potential Initiation; Coincidence Detection;
Implementer(s):  Schaefer, Andreas [a.schaefer at ucl.ac.uk];
Search NeuronDB for information about:  Neocortical pyramidal neuron: deep; I Na,t; I A; I K; I M; I K,Ca; I Calcium;
Files displayed below are from the implementation
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weblink
weblink_files
readme.html
                            
 Andreas Schaefer

Dendritic Arborization and Coupling

Schaefer,A.T., Larkum, M.E., Sakmann,B., and Roth,A. (2003). Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern. Journal of Neurophysiology 89:3143-3154 (PubMed)

Additional Material

Coupling in simulation – a movie (2.2 MB)

The algorithm for generating synthetic Neurons

NEURON source codes for the above movie

NEURON source codes for the above movie (Version 0.9.1 25.8.03)

Related Publications

Larkum,M.E., Zhu,J.J., and Sakmann,B. (1999). A new cellular mechanism for coupling inputs arriving at different cortical layers. Nature 398, 338-341. (PubMed)

Spruston,N. (2003). Branching out: a new idea for dendritic function. Focus on "Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern". J Neurophysiol 89, 2887-2888. (PubMed)

Hausser,M. and Mel,B. (2003). Dendrites: bug or feature? Curr.Opin.Neurobiol. 13, 372-383. (PubMed)

For electronic versions of the publictions or questions regarding the additional material or comments please eMail schaefer@mpimf-heidelberg.mpg.de

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