ModelDB: Spiking neuron model of the basal ganglia (Humphries et al 2006)

Spiking neuron model of the basal ganglia (Humphries et al 2006)

Accession: 83559

A spiking neuron model of the basal ganglia (BG) circuit (striatum, STN, GP, SNr). Includes: parallel anatomical channels; tonic dopamine; dopamine receptors in striatum, STN, and GP; burst-firing in STN; GABAa, AMPA, and NMDA currents; effects of synaptic location. Model demonstrates selection and switching of input signals. Replicates experimental data on changes in slow-wave (<1 Hz) and gamma-band oscillations within BG nuclei following lesions and pharmacological manipulations.
Reference: Humphries MD, Stewart RD, Gurney KN (2006) A physiologically plausible model of action selection and oscillatory activity in the basal ganglia. J Neurosci 26:12921-42 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Network;
Brain Region(s)/Organism:	Basal ganglia;
Cell Type(s):	Neostriatal spiny neuron; Subthalamic projection neuron; Globus pallidus neuron;
Channel(s):
Gap Junctions:
Receptor(s):	Dopaminergic Receptor;
Gene(s):
Transmitter(s):	Dopamine; Gaba; Glutamate;
Simulation Environment:	MATLAB;
Model Concept(s):	Oscillations; Parkinson's; Action Selection/Decision Making; Sleep; Rebound firing;
Implementer(s):	Humphries, Mark D [m.d.humphries at shef.ac.uk];

Search NeuronDB for information about: Neostriatal spiny neuron; Dopaminergic Receptor; Dopamine; Gaba; Glutamate;

Model files

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BG_spiking_model

BATCH_BG_heterogenous_AMPA_NMDA.m

BATCH_BG_heterogenous_AMPA_NMDA2.m

batch_selection_grid_DA.m

BG_GHS_inputs.m

BG_net_shunt_AMPA_NMDA.m

BG_net_shunt_AMPA_NMDA2.m

combine_stngpe_analysis.m

extract_spikes.m

GHS_LIF_solver_shunt_AMPA_NMDA.c

GHS_LIF_solver_shunt_AMPA_NMDA.dll

GHS_LIF_solver_shunt_AMPA_NMDA.mexa64

GHS_LIF_solver_shunt_AMPA_NMDA.mexglx

models_as_individuals.m

batch_analyse_stngpe.m

single_run5_1a.m

single_run5_1b.m

single_run5_1c.m

single_run5_1d.m

single_run5_2a.m

single_run5_2b.m

single_run5_2c.m

single_run5_2d.m

single_run5_3a.m

single_run5_3b.m

single_run5_3c.m

single_run5_3d.m

single_run5_4a.m

single_run5_4b.m

single_run5_4c.m

single_run5_4d.m

single_run5_5a.m

single_run5_5b.m

single_run5_5c.m

single_run5_5d.m

single_run5_6d.m

User Manual.pdf

Please see the "User Manual.pdf" for an introduction to this
Spiking Neuron Basal Ganglia Model.

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