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Temporal decorrelation by intrinsic cellular dynamics (Wang et al 2003)
Accession: 84593
"... Recent investigations in primary visual (V1) cortical neurons have demonstrated that adaptation to prolonged changes in stimulus contrast is mediated in part through intrinsic ionic currents, a Ca2+ activated K+ current (IKCa) and especially a Na+ activated K+ current (IKNa). The present study was designed to test the hypothesis that the activation of adaptation ionic currents may provide a cellular mechanism for temporal decorrelation in V1. A conductance-based neuron model was simulated, which included an IKCa and an IKNa. We show that the model neuron reproduces the adaptive behavior of V1 neurons in response to high contrast inputs. ...". See paper for details and more.
Model Information (Click on a link to find other models with that property)
Model Type:  
Brain Region(s)/Organism:  
Cell Type(s):  Neocortical pyramidal neuron: superficial;  
Channel(s):  I Na,t; I L high threshold; I K; I Calcium; I Potassium;  
Gap Junctions:  
Receptor(s):  
Gene(s):  
Transmitter(s):  
Simulation Environment:  C or C++ program;
Model Concept(s):  Ion Channel Kinetics; Temporal Pattern Generation; Oscillations; Calcium dynamics;
Implementer(s):  Wang, Xiao-Jing [xjwang at yale.edu];
Search NeuronDB for information about:  Neocortical pyramidal neuron: superficial; I Na,t; I L high threshold; I K; I Calcium; I Potassium;
\
decorr-model
images
readme.html
header.h
myutils.c
nrutil.c
nrutil.h
driver.c
rk4.c
                            

This is the readme for the model code associated with the publication

Wang XJ, Liu Y, Sanchez-Vives MV, McCormick DA.  Related Articles,
Links Free Full Text Adaptation and temporal decorrelation by single
neurons in the primary visual cortex.  J Neurophysiol. 2003
Jun;89(6):3279-93. Epub 2003 Mar 20

Usage:
Extract the archive and cd to the newly created directory.
Compile with a command like:
gcc -o run driver.c -lm
Then run with:
./run

After a minute the program completes and data files are generated for
figure 1 from the paper.

out.dat.a3 corresponds to figure 1A:

fig1A

f_inst.dat.a3 corresponds to figure 1D:

fig1D

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