| Endothelin action on pituitary latotrophs (Bertram et al. 2006) |
| Accession: 91899 |
Endothelin (ET-1, -2, and -3 designate three genes which produce different endothelin isopeptides) is a prolactin inhibiting substance of hypothalmic origin. ET-1 binding is part of at least four G protein signaling pathways in lactotrophs. The sequence of events in these pathways following the presentation of nano- and pico-molar concentrations of ET-1 is modeled in the paper.
Reference: Bertram R, Tabak J, Toporikova N, Freeman ME (2006) Endothelin action on pituitary lactotrophs: one receptor, many GTP-binding proteins. Sci STKE 2006:pe4 [PubMed] |
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Note from ModelDB Administrator: the below is a copy of the web page
http://www.math.fsu.edu/~bertram/software/pituitary/STKE_06/
made on May 8th, 2007.
Software for "Endothelin Action on Pituitary Lactotrophs:
One receptor, Many GTP-Binding Proteins", Science STKE, 2006(319):pe4,
2006, by
R. Bertram, J. Tabak, N. Toporikova, and M. E. Freeman
- First figure, simulation of nanomolar concentrations of
endothelin-1.
Figure 1
- Second figure, simulation of picomolar concentrations of
endothelin-1.
Figure 2
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