ModelDB: Model of DARPP-32 phosphorylation in striatal medium spiny neurons (Lindskog et al. 2006)

Model of DARPP-32 phosphorylation in striatal medium spiny neurons (Lindskog et al. 2006)

Accession: 97743

The work describes a model of how transient calcium and dopamine inputs might affect phosphorylation of DARPP-32 in the medium spiny neurons in the striatum. The model is relevant for understanding both the "three-factor rule" for synaptic plasticity in corticostriatal synapses, and also for relating reinforcement learning theories to biology.
Reference: Lindskog M, Kim M, Wikstrom MA, Blackwell KT, Kotaleski JH (2006) Transient calcium and dopamine increase PKA activity and DARPP-32 phosphorylation. PLoS Comput Biol 2:e119 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:
Brain Region(s)/Organism:
Cell Type(s):	Neostriatal spiny neuron;
Channel(s):	I Calcium;
Gap Junctions:
Receptor(s):	D1; D2;
Gene(s):	D1 DRD1A; D2 DRD2;
Transmitter(s):	Dopamine;
Simulation Environment:	XPP;
Model Concept(s):	Long-term Synaptic Plasticity; Signaling pathways; Reinforcement Learning;
Implementer(s):

Search NeuronDB for information about: Neostriatal spiny neuron; D1; D2; I Calcium; Dopamine;

Model files

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This is the readme for the XPP model associated with the paper: Lindskog M, Kim M, Wikstrom MA, Blackwell KT, Kotaleski JH (2006) Transient calcium and dopamine increase PKA activity and DARPP-32 phosphorylation. PLoS Comput Biol 2:e119 This model contains corrections for several typos that appeared in the paper. Please see the top of the code for details. Model usage: Start XPP with the model with a command like xppaut DARPPmodel_2006.ode Run the model by clicking on Initialconds -> (G)o After the model is done running you can create the panels of Fig 5A-F by plotting the variables "PKAc", "p34", "PP1", "ratio", "p75" and 2*"PKAr". To plot Fig 5A, for example, click on Graphic Stuff -> (E)dit curve then press Enter on the keyboard Replace the Y-Axis: field with the value PKAc click OK Click on Window/Zoom -> (F)it then you will have a graph that looks like: screenshot

This XPP file was supplied by Dr Jeanette Kotaleski jeanette@csc.kth.se

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