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NEURON mod files from the paper:
C. Savio Chan, Jaime N. Guzman, Ema Ilijic, Jeff N. Mercer, Caroline
Rick, Tatiana Tkatch, Gloria E. Meredith & D. James Surmeier
'Rejuvenation' protects neurons in mouse models of Parkinson's
disease, Nature 447, 1081-1086(28 June 2007)
This is the model demonstrated in Supplementary Information:
Figure S5: Computer simulation of the role of HCN gating in pacemaking
of DA neurons. a. NEURON simulation of autonomous spiking in an SNc DA
neuron. Elimination of voltage-dependent Na+ channels revealed Cav1.3
L-type Ca2+ channel dependent pacemaker potentials, similar to that
found in recorded neurons. b. Elevating intracellular cAMP in the
model following the model of Siegelbaum et al. 48 produced a rightward
shift in the voltage of activation for HCN channels. This shift
increased HCN currents in a simulated voltage clamp experiment in much
the same way as seen experimentally (see Supplementary Figs. 3,
4). c. Elimination of Cav1.3 L-type Ca2+ channel silenced pacemaking
activity in the model SNc DA neuron, resembling experimental
observation. Elevating cAMP levels and shifting HCN voltage
dependence restored pacemaking activity in the face of Cav1.3 L-type
Ca2+ channel blockade.
Sample model usage:
Start the model with auto-launch in ModelDB or download and extract
the archive and then
under mswin:
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1) compile the mod files with mknrndll (in the mod directory)
2) double click on the mosinit.hoc file
under linux/unix:
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1) compile the mod files with nrnivmodl (in the mod directory)
2) start with "nrngui mosinit.hoc" in the rejuvenation directory
Once the simulation is started:
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1) Click Init & Run
2) Click the box to turn off Na channels to see the Cav1.3 L-type Ca2+
channel dependent pacemaker potentials
If all goes well you will create a figure similar to figure S5A in the
paper:
Questions on how to use this model can be directed to Josh Held,
j-held@northwestern.edu
20120112 kv4hh.mod solve method updated to cnexp from euler as per
http://www.neuron.yale.edu/phpbb/viewtopic.php?f=28&t=592
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