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Membrane Channels: Inventory of genes and gene products
This page gives a complete overview of the main types of membrane channels that have been identified in excitable membranes. The list of membrane currents for NeuronDB is a subset of this inventory.
The inventory is based on Hille (2001). The inventory is in terms of genes and gene products.
Na channels
Ca channels
K channels and related channels
Gene family of Na channels Biophysical properties
| | | | | | | | | Nav1.1 | SCN1A | 2q24 |
| | Nav1.2 | SCN2A | 2q23-24 |
| | Nav1.3 | SCN3A | 2q24 |
| | Nav1.4 | SCN4A | 17q23-25 |
| | Nav1.5 | SCN5A | 3p21 |
| | Nav1.6 | SCN8A | 12q13 |
| | Nav1.7 | SCN9A | 2q24 |
| | Nav1.8 | SCN10A | 3p22-24 |
| | Nav1.9 | SCN11A | 3p21-24 |
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Abbreviations:
- Nav: Sodium channel, voltage-gated
Gene family of Ca channels
| HVA | L | Cav1.1 | CACNA1S | 1q31-32 |
| Cav1.2 | CACNA1C | 12p13.33 |
| Cav1.3 | CACNA1D | 3p14.3 |
| Cav1.4 | CACNA1F | Xp11.23 |
| P/Q | Cav2.1 | CACNA1A | 19p13 |
| N | Cav2.2 | CACNA1B | 9q34 |
| R | Cav2.3 | CACNA1E | 1q25-31 |
| LVA T | Cav3.1 | CACNA1G | 17q22 |
| Cav3.2 | CACNA1H | 16p13.2 |
| Cav3.3 | CACNA1I | 22q12 |
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Abbreviations:
- Cav: Calcium channel, voltage-gated
- HVA: High voltage-activated, high-threshold
- LVA: Low voltage-activated, low-threshold
- L-type: Longlasting, high-threshold
- T-type: Transient, low-threshold
- N-type: Neither L- nor T-type.
- P/Q-type: sensitive to w-Aga IVA
- R-type: resistent to w-Aga IVA
Gene family of K and related channels Biophysical properties
| 6TM | NCN1 | HCN | Hyperpolarization-activated | Nonselective cation channels |
| CNG1 | CNG | Cyclic nucleotide-gated |
| eag | KCNH | Voltage-gated
ether a-go-go | |
| akt1 | | Plant inward rectifiers | |
| pak1 | | Paramecium | |
| mslo | KCNM | Large conductance (BK)
voltage/calcium-gated | |
| SK1 | KCNN | Small and intermdiate
conductance calcium-activated | |
| Kv1.1 | KCNA | Voltage-gated shakers | Delayed-rectifiers and A-type |
| Kv2.1 | KCNB | Voltage-gated shabs |
| Kv3.1 | KCNC | Voltage-gated shaws |
| Kv4.1 | KCND | Voltage-gated shals |
| Kv5.1 | | Voltage-gated outlier |
| Kv6.1 | | Modifiers/silencers |
| Kv7.1=KCNQ1 | KCNQX=Kv7.X | Voltage-gated KCNQs | Slow delayed-rectifiers (M-Current is a heteromeric assembly of KCNQ2 and KCNQ3 subunits) |
| Kv8.1 | | Modifiers/silencers | Delayed-rectifiers |
| Kv9.1 | KCNS | Modifiers/silencers |
| 2TM | Kir4.1 | KCNH | Inward rectifiers | Classical inward rectifiers |
| Kir7.1 |
| Kir1.1 |
| Kir2.1 |
| Kir5.1 |
| Kir6.1 | ATP-sensitive |
| Kir3.1 | G-protein-coupled |
| 4TM | TWIK | KCNK | 2-P-domain K leaks | |
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Abbreviations:
- Kv: Potassium channel, voltage-gated
- Kir: Inward-rectifying potassium channel
- KCNQ: Potassium channel, voltage gated, originally known as KvLQT, the gene responsible for the Long QT-interval (in electrocardiograms) disease
Reference
Hille, B. (2001) Ion Channels of Excitable Membrane (3rd Edition). Sunderland, Mass. Sinauer Associates, Inc.
K channels from the cardiovascular cell physiology group at Philipps-University Marburg
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