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The Olfactory Receptor Resource Area, is an area that contains resources and tools, integrated with ORDB to help the community of olfactory researchers understand olfactory receptor structure and function. The Tools and Resources area of ORDB is under constant flux: As new sequences are deposited, more resources are being created and added. All of the links are active. Tools and resources that have no active links will be available in the near future
- Blast search. Input any sequence and search for homology with ORDB receptors.
- Automatic generation of a "sequential name" for a cloned receptor. Investigators can input sequences of their cloned receptors and receive as an output a sequencial name of the type "ORL1234" depending on the chronological order the receptor was inputed in ORDB. Than name becomes the receptor's ORDB UID and part of its multi-level dscriptor.
- Multilevel, one line attribute descriptor of a particular receptor.
Nomenclature of ORs has been a very challenging issue. Most ORs have been named by the
laboratories that cloned them using several intralaboratory criteria for naming.
The use of a database makes multi-level information as an alternative to a single name
for a receptor. The multi-level descriptor is generated by the compination of several
fields that include:
- species
- ORDB ID (sequencial name)
- laboratory (trivial) name
- phylogenetic classification (following the rules established by Lancet et al)
- chromosome information
- tissue expressed
- full-length or partial clone
- ligand information.
- Retrieve publications on olfactory receptors or on olfaction from PubMed that have been published within the last 90 days.
- Interactive (in the near future) Alignments of receptors ("Clicking" on the name of each receptor will produce its entry in ORDB in a new window):
- All full-length ORLs (clustalW, non anchored allignment, as of 6/28/99)
- ORLs, full-length and partials (clustalW, non anchored allignment,all receptors in ORDB as of 11/98)
- All CCRs(clustalW, non anchored allignment)
- All VNRs (clustalW, non anchored allignment)
- All IORs (clustalW, non anchored allignment)
- All FPRs (clustalW, non anchored allignment)
- Interactive (in the near future) Phylogenetic trees of receptors ("Clicking" on the name of each receptor will produce its entry in ORDB in a new window):
- Full-length ORLs with other GPCRs as outgroups(phylogram, ClustalX alignment,as of 11/98)
- Full-length ORLs with other GPCRs as outgroups(unrooted tree, ClustalX alignment,as of 11/98)
- Full-length ORLs(phylogram, ClustalX alignment,as of 6/28/99)
- Full-length ORLs(unrooted tree, ClustalX alignment,as of 6/28/99)
- ORLs, full-length and partials (unrooted tree, ClustalX alignment,as of 11/98)
- ORLs, full-length and partials (phylogram, ClustalX alignment, distance correction,as of 11/98)
- All CCRs(phylogram, ClustalX alignment)
- All CCRs(unrooted tree, ClustalX alignment, distance correction)
- All FPRs(phylogram, ClustalX alignment)
- All IORs(phylogram, ClustalX alignment)
- All IORs(unrooted tree, ClustalX alignment, distance correction)
- All VNRs(phylogram, ClustalX alignment)
- All VNRs(unrooted tree, ClustalX alignment, distance correction)
- Interactive (in the near future) Motif stricture diagrams of receptors ("Clicking" on the name of each receptor will produce its entry in ORDB in a new window):
- full-length ORLs (MEME, based on motifs described in: Skoufos E. (1999) Receptors and Channels, 999;6(5):401-13 PUBMED)
- A "snake" diagram of an ORL with ORL-specific motifs assigned (based on motifs described in: Skoufos E. (1999) Receptors and Channels, 1999;6(5):401-13 PUBMED)