NeuronDB: Neuron Database User: Public
SenseLab  Home Data Search Schema Login	[Data] Neural Compartmental receptors Name NA-91 Description Property present -1 Neuron Olfactory bulb mitral cell   show other CF-Compartment Distal basal dendrite   show other Receptor NMDA   show other Connect Note (autoreceptors) mitral cell secondary dendrite (Dbd) References Notes (>14<). Both ionotropic NMDA and non-NMDA autoreceptors are activated by glutamate released from primary and secondary dendrites. In contrast to non-NMDA autoreceptors, NMDA autoreceptors are almost exclusively located on secondary dendrites and their activation generates a large and sustained self-excitation. Both intracellularly evoked and miniature NMDA-R mediated synaptic potentials are blocked by intracellular BAPTA and result from a calcium-dependent release of glutamate (>189<).Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells (>234<). connectivity Other categories referring to "NA-91"   Revisions: 2 Last time: 6/14/2001 8:45:31 AM Reviewer: Michele Migliore Owner: EAV/CR Schema Administrator
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