Brain Pharm: Brain Pharmacology Database User: Public
SenseLab  Home Data Search Schema Login	[Data] Pathological mechanism Name Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine. Description Hypothesis Nicotinic Receptor Hypothesis   show other Extracelular pathological element β-Amyloid   show other Intracelular pathological element Pathological action Antagonizes   show other Process Process action Transmitter(s) Receptor(s) Cholinergic Receptors   show other Nicotinic   show other Channel(s) Pharmacological Agent Choline   show other Nicotine   show other Acetyl Choline   show other Pharmacological Action Opposes   show other Brain region Hippocampus   show other Neuron Cell model Brain slice preparations   show other Cellular compartment PubMed ID 16303255 Citation AlzWeb Notes Spencer, J. P., Weil, A., Hill, K., Hussain, I., Richardson, J. C., Cusdin, F. S., et al. (2006). Transgenic mice over-expressing human beta-amyloid have functional nicotinic alpha 7 receptors. Neuroscience, 137(3), 795-805. Amyloid beta peptide(1-42) antagonized human alpha7 responses in a partially reversible fashion; no agonist effects were detected. A similar inhibition of mouse alpha 7 was also observed. Hippocampal GABAergic interneurones in slices from beta-amyloid over-expressing mice still possess alpha 7 receptor-mediated currents. Pathology Alzheimer   show other Stage Early   show other Question Claim Other categories referring to "Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine."   Revisions: 4 Last time: 11/21/2008 10:53:18 AM Reviewer: Pradeep Mutalik Owner: Pradeep Mutalik
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