Brain Pharm: Brain Pharmacology Database User: Public
SenseLab  Home Data Search Schema Login	[Data] Pathological mechanism Name Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice Description Hypothesis Dendritic Spine Hypothesis   show other Extracelular pathological element β-Amyloid   show other Intracelular pathological element Pathological action Reduces   show other Process Dendritic spine density   show other Process action Transmitter(s) Receptor(s) Channel(s) Pharmacological Agent Pharmacological Action Brain region Hippocampus   show other Neuron Cell model Golgi impregnation - Animal post-mortem brains   show other Cellular compartment Dendrite   show other PubMed ID 18632740 Citation AlzWeb Notes Three-dimensional analysis of 21 507 dendritic spines in the dentate gyrus, a region crucial for learning and memory, revealed a substantial decrease in the frequency of large spines in plaque-free regions of APP/PS1 mice. Plaque-related dendrites also show striking alterations in spine density and morphology. However, plaques occupy only 3.9% of the molecular layer volume. Because large spines are considered to be the physical traces of long-term memory, widespread decrease in the frequency of large spines likely contributes to the cognitive impairments observed in this AD model. Knafo, S., Alonso-Nanclares, L., Gonzalez-Soriano, J., Merino-Serrais, P., Fernaud-Espinosa, I., Ferrer, I., et al. (2008). Widespread changes in dendritic spines in a model of alzheimer's disease. Cerebral Cortex Pathology Alzheimer   show other Stage Early   show other Question Claim Loss/alteration of dendritic spines in early Alzheimer's   show other Other categories referring to "Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice"   Revisions: 1 Last time: 7/30/2008 6:20:41 PM Reviewer: Pradeep Mutalik Owner: Pradeep Mutalik
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