Brain Pharm: Brain Pharmacology Database User: Public
SenseLab  Home Data Search Schema Login	[Data] Pathological mechanism Name Histidine associating compounds block Abeta Channel activity and cytotoxicity Description Hypothesis Abeta Channel Hypothesis   show other Extracelular pathological element β-Amyloid   show other Intracelular pathological element Pathological action Induces   show other Process Cytotoxicity   show other Process action Transmitter(s) Receptor(s) Channel(s) Pharmacological Agent Histidine-associating Compounds   show other Pharmacological Action Blocks   show other Brain region Neuron Cell model Cellular compartment PubMed ID 18723589 Citation AlzWeb Notes The opening of the Alzheimer's Abeta channel permits the flux of calcium into the cell, thus critically disturbing intracellular ion homeostasis. Peptide segments which include the characteristic histidine diad, His13 and His14, efficiently block the Abeta channel activity blocking Abeta cytotoxicity. Compounds that are known to have histidine association capacity, such as Ni(2+), imidazole, histidine and a series of histidine-related compounds were effective at blocking both Abeta channels and preventing Abeta cytotoxicity. The efficiency of protection of histidine-related compounds was correlated with the number of imidazole side chains in the blocker compounds. Efficiency of histidine-associating compounds for blocking the Alzheimer's A{beta} channel activity and cytotoxicity.Arispe NJ, Diaz JC, Flora M. Biophys J. 2008 Aug 22. Pathology Alzheimer   show other Stage Early   show other Question Claim Other categories referring to "Histidine associating compounds block Abeta Channel activity and cytotoxicity"   Revisions: 4 Last time: 9/5/2008 12:55:53 PM Reviewer: Pradeep Mutalik Owner: Pradeep Mutalik
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